Echocardiographic determinants of mitral early flow propagation velocity

Paolo Barbier, Antonio Grimaldi, Marina Alimento, Giovanni Berna, Maurizio D. Guazzi

Research output: Contribution to journalArticlepeer-review


Transmitral color Doppler early diastolic flow propagation velocity (Vp) has been correlated with the left ventricular (LV) relaxation time constant τ in dilated cardiomyopathy and ischemic heart disease. The aim of this study was to investigate the independent influence of LV systolic function and geometry, and of LV relaxation, on Vp in an unselected outpatient population. We studied 30 normal subjects and 130 patients (hypertensive LV hypertrophy, aortic valve stenosis or prosthesis, hypertrophic cardiomyopathy, coronary artery disease, dilated cardiomyopathy, aortic or mitral valve regurgitation). In all, we noninvasively measured LV geometry, mass, systolic function, wall motion dyssynergy, and diastolic function (abnormal relaxation or restrictive LV Doppler filling patterns). The Vp was similar in normal subjects and in patients (51 ± 14 vs 53 ± 25 cm/s). In normal subjects, the determinants of Vp at multiple regression analysis were isovolumic relaxation time, 2-dimensional cardiac index, and mitral E-wave velocity-time integral. In all, the main determinants were LV ejection fraction, percent of segmental wall dyssynergy, and isovolumic relaxation time and age. The Vp was highest in hypertrophic (75 ± 25 cm/s, p

Original languageEnglish
Pages (from-to)613-619
Number of pages7
JournalThe American Journal of Cardiology
Issue number6
Publication statusPublished - Sep 15 2002

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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