Ecological impact of isolated cognitive relapses in MS

Research output: Contribution to journalArticle


Isolated cognitive relapses (ICRs) are transient deficits in cognitive performance that are the only presentation of a multiple sclerosis (MS) relapse. Here, we evaluated the impact of ICRs on cognitive difficulties in daily activities (assessed with the Multiple Sclerosis Neuropsychological Screening Questionnaire, Informant Version (MSNQ-I)) to characterize ICRs’ clinical relevance. We used 2-year-long retrospective data to compare 15 relapsing-remitting MS (RRMS) patients with ICRs with 57 RRMS patients presenting an asymptomatic gadolinium enhancing lesion (and no-ICRs). ICRs were associated not only with neuropsychological performance decline but also with an increase in the daily cognitive difficulties. These findings support the ecological relevance of ICRs.

Original languageEnglish
JournalMultiple Sclerosis Journal
Publication statusAccepted/In press - Jan 1 2018



  • cognition
  • quality of life
  • Relapses

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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