Ecstasy (MDMA)-addicted subjects show increased serum levels of brain-derived neurotrophic factor, independently from a rise of drug-induced psychotic symptoms

Francesco Angelucci; Valerio Ricci; Giovanni Martinotti; Ilaria Palladino; Gianfranco Spalletta; Carlo Caltagirone; Pietro Bria

doi:10.1111/j.1369-1600.2010.00221.x

Ecstasy (MDMA)-addicted subjects show increased serum levels of brain-derived neurotrophic factor, independently from a rise of drug-induced psychotic symptoms

Francesco Angelucci, Valerio Ricci, Giovanni Martinotti, Ilaria Palladino, Gianfranco Spalletta, Carlo Caltagirone, Pietro Bria

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

The recreational drug 'ecstasy' [3,4-methylenedioxymethamphetamine (MDMA)] exerts a potent action on central serotonergic and dopaminergic neurons. These neurons utilize neurotrophins for their survival and function. In order to explore MDMA effects on neurotrophins, we measured by enzyme-linked immunosorbent assay the serum levels of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in 'ecstasy-addicted', 'ecstasy-addicted with signs of psychosis' and 'healthy' subjects. We found that BDNF serum levels were significantly increased in both groups of 'ecstasy-addicted' as compared with 'healthy subjects', supporting the hypothesis that BDNF is involved in MDMA action.

Original language	English
Pages (from-to)	365-367
Number of pages	3
Journal	Addiction Biology
Volume	15
Issue number	3
DOIs	https://doi.org/10.1111/j.1369-1600.2010.00221.x
Publication status	Published - 2010

Keywords

Addiction
BDNF
Ecstasy
MDMA
NGF
Psychosis

ASJC Scopus subject areas

Medicine (miscellaneous)
Psychiatry and Mental health
Pharmacology
Medicine(all)

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Ecstasy (MDMA)-addicted subjects show increased serum levels of brain-derived neurotrophic factor, independently from a rise of drug-induced psychotic symptoms. / Angelucci, Francesco; Ricci, Valerio; Martinotti, Giovanni; Palladino, Ilaria; Spalletta, Gianfranco ; Caltagirone, Carlo; Bria, Pietro.

In: Addiction Biology, Vol. 15, No. 3, 2010, p. 365-367.

Research output: Contribution to journal › Article › peer-review

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AU - Spalletta, Gianfranco

AU - Caltagirone, Carlo

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