TY - JOUR
T1 - Ectopic ACTH syndrome due to occult bronchial carcinoid
AU - Corsello, Salvatore Maria
AU - Fintini, Danilo
AU - Lovicu, Rosa Maria
AU - Paragliola, Rosa Maria
AU - Rufini, Vittoria
AU - Simonetti, Giovanni
AU - Pontecorvi, Alfredo
PY - 2009/7
Y1 - 2009/7
N2 - Cushing syndrome (CS) is certainly one of the most challenging endocrine disorders. The greatest problem involves the differentiation between Cushing disease and ectopic ACTH syndrome. We report a patient with ACTH-dependent CS who elsewhere underwent unsuccessful transsphenoidal surgery for a pituitary microadenoma. In our institution, high resolution CT didn't show any chest tumor but laboratory data were consistent with ectopic ACTH secretion.Only In-111 Octreoscan, integrated with SPECT-CT and virtual bronchoscopy, allowed the diagnosis of ectopic Cushing syndrome due to occult bronchial carcinoid. Successful surgery was then performed.
AB - Cushing syndrome (CS) is certainly one of the most challenging endocrine disorders. The greatest problem involves the differentiation between Cushing disease and ectopic ACTH syndrome. We report a patient with ACTH-dependent CS who elsewhere underwent unsuccessful transsphenoidal surgery for a pituitary microadenoma. In our institution, high resolution CT didn't show any chest tumor but laboratory data were consistent with ectopic ACTH secretion.Only In-111 Octreoscan, integrated with SPECT-CT and virtual bronchoscopy, allowed the diagnosis of ectopic Cushing syndrome due to occult bronchial carcinoid. Successful surgery was then performed.
KW - 111 In-Octreoscan
KW - Bilateral inferior petrosal sinus sampling
KW - Bronchial carcinoid
KW - Ectopic Cushing syndrome
KW - SPECT-CT
KW - Virtual bronchoscopy
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U2 - 10.1097/RLU.0b013e3181a7d22e
DO - 10.1097/RLU.0b013e3181a7d22e
M3 - Article
C2 - 19542957
AN - SCOPUS:67650645739
VL - 34
SP - 459
EP - 461
JO - Clinical Nuclear Medicine
JF - Clinical Nuclear Medicine
SN - 0363-9762
IS - 7
ER -