EDA fibronectin–TLR4 axis sustains megakaryocyte expansion and inflammation in bone marrow fibrosis

A. Malara, C. Gruppi, V. Abbonante, D. Cattaneo, L. De Marco, M. Massa, A. Iurlo, U. Gianelli, C.L. Balduini, M.E. Tira, A.F. Muro, A.K. Chauhan, V. Rosti, G. Barosi, A. Balduini

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)587-604
Number of pages18
JournalJournal of Experimental Medicine
Volume216
Issue number3
DOIs
Publication statusPublished - 2019

Keywords

  • fibronectin
  • fibronectin eda
  • immunoglobulin enhancer binding protein
  • interleukin 6
  • mitogen activated protein kinase 1
  • mitogen activated protein kinase 3
  • romiplostim
  • STAT5 protein
  • thrombopoietin
  • toll like receptor 4
  • unclassified drug
  • animal experiment
  • animal model
  • Article
  • cell differentiation
  • cell expansion
  • cell proliferation
  • controlled study
  • enzyme linked immunosorbent assay
  • exon
  • extramedullary hematopoiesis
  • hematopoietic tissue
  • human
  • inflammation
  • megakaryocyte
  • megakaryopoiesis
  • mouse
  • myelofibrosis
  • nonhuman
  • phenotype
  • priority journal
  • second cervical vertebra
  • signal transduction
  • splenomegaly
  • stem cell

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