EDA fibronectin–TLR4 axis sustains megakaryocyte expansion and inflammation in bone marrow fibrosis

A. Malara; C. Gruppi; V. Abbonante; D. Cattaneo; L. De Marco; M. Massa; A. Iurlo; U. Gianelli; C.L. Balduini; M.E. Tira; A.F. Muro; A.K. Chauhan; V. Rosti; G. Barosi; A. Balduini

doi:10.1084/jem.20181074

EDA fibronectin–TLR4 axis sustains megakaryocyte expansion and inflammation in bone marrow fibrosis

A. Malara, C. Gruppi, V. Abbonante, D. Cattaneo, L. De Marco, M. Massa, A. Iurlo, U. Gianelli, C.L. Balduini, M.E. Tira, A.F. Muro, A.K. Chauhan, V. Rosti, G. Barosi, A. Balduini

Research output: Contribution to journal › Article

Original language	English
Pages (from-to)	587-604
Number of pages	18
Journal	Journal of Experimental Medicine
Volume	216
Issue number	3
DOIs	https://doi.org/10.1084/jem.20181074
Publication status	Published - 2019

Keywords

fibronectin
fibronectin eda
immunoglobulin enhancer binding protein
interleukin 6
mitogen activated protein kinase 1
mitogen activated protein kinase 3
romiplostim
STAT5 protein
thrombopoietin
toll like receptor 4
unclassified drug
animal experiment
animal model
Article
cell differentiation
cell expansion
cell proliferation
controlled study
enzyme linked immunosorbent assay
exon
extramedullary hematopoiesis
hematopoietic tissue
human
inflammation
megakaryocyte
megakaryopoiesis
mouse
myelofibrosis
nonhuman
phenotype
priority journal
second cervical vertebra
signal transduction
splenomegaly
stem cell

Cite this

Malara, A., Gruppi, C., Abbonante, V., Cattaneo, D., De Marco, L., Massa, M., ... Balduini, A. (2019). EDA fibronectin–TLR4 axis sustains megakaryocyte expansion and inflammation in bone marrow fibrosis. Journal of Experimental Medicine, 216(3), 587-604. https://doi.org/10.1084/jem.20181074

EDA fibronectin–TLR4 axis sustains megakaryocyte expansion and inflammation in bone marrow fibrosis. / Malara, A.; Gruppi, C.; Abbonante, V.; Cattaneo, D.; De Marco, L.; Massa, M.; Iurlo, A.; Gianelli, U.; Balduini, C.L.; Tira, M.E.; Muro, A.F.; Chauhan, A.K.; Rosti, V.; Barosi, G.; Balduini, A.

In: Journal of Experimental Medicine, Vol. 216, No. 3, 2019, p. 587-604.

Research output: Contribution to journal › Article

Malara, A, Gruppi, C, Abbonante, V, Cattaneo, D, De Marco, L , Massa, M , Iurlo, A, Gianelli, U, Balduini, CL, Tira, ME, Muro, AF, Chauhan, AK, Rosti, V, Barosi, G & Balduini, A 2019, 'EDA fibronectin–TLR4 axis sustains megakaryocyte expansion and inflammation in bone marrow fibrosis', Journal of Experimental Medicine, vol. 216, no. 3, pp. 587-604. https://doi.org/10.1084/jem.20181074

Malara, A. ; Gruppi, C. ; Abbonante, V. ; Cattaneo, D. ; De Marco, L. ; Massa, M. ; Iurlo, A. ; Gianelli, U. ; Balduini, C.L. ; Tira, M.E. ; Muro, A.F. ; Chauhan, A.K. ; Rosti, V. ; Barosi, G. ; Balduini, A. / EDA fibronectin–TLR4 axis sustains megakaryocyte expansion and inflammation in bone marrow fibrosis. In: Journal of Experimental Medicine. 2019 ; Vol. 216, No. 3. pp. 587-604.

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title = "EDA fibronectin–TLR4 axis sustains megakaryocyte expansion and inflammation in bone marrow fibrosis",

keywords = "fibronectin, fibronectin eda, immunoglobulin enhancer binding protein, interleukin 6, mitogen activated protein kinase 1, mitogen activated protein kinase 3, romiplostim, STAT5 protein, thrombopoietin, toll like receptor 4, unclassified drug, animal experiment, animal model, Article, cell differentiation, cell expansion, cell proliferation, controlled study, enzyme linked immunosorbent assay, exon, extramedullary hematopoiesis, hematopoietic tissue, human, inflammation, megakaryocyte, megakaryopoiesis, mouse, myelofibrosis, nonhuman, phenotype, priority journal, second cervical vertebra, signal transduction, splenomegaly, stem cell",

author = "A. Malara and C. Gruppi and V. Abbonante and D. Cattaneo and {De Marco}, L. and M. Massa and A. Iurlo and U. Gianelli and C.L. Balduini and M.E. Tira and A.F. Muro and A.K. Chauhan and V. Rosti and G. Barosi and A. Balduini",

note = "Export Date: 21 August 2019 CODEN: JEMEA Correspondence Address: Balduini, A.; Department of Molecular Medicine, University of PaviaItaly; email: alessandra.balduini@tufts.edu",

year = "2019",

doi = "10.1084/jem.20181074",

language = "English",

volume = "216",

pages = "587--604",

journal = "Journal of Experimental Medicine",

issn = "0022-1007",

publisher = "Rockefeller University Press",

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TY - JOUR

T1 - EDA fibronectin–TLR4 axis sustains megakaryocyte expansion and inflammation in bone marrow fibrosis

AU - Malara, A.

AU - Gruppi, C.

AU - Abbonante, V.

AU - Cattaneo, D.

AU - De Marco, L.

AU - Massa, M.

AU - Iurlo, A.

AU - Gianelli, U.

AU - Balduini, C.L.

AU - Tira, M.E.

AU - Muro, A.F.

AU - Chauhan, A.K.

AU - Rosti, V.

AU - Barosi, G.

AU - Balduini, A.

N1 - Export Date: 21 August 2019 CODEN: JEMEA Correspondence Address: Balduini, A.; Department of Molecular Medicine, University of PaviaItaly; email: alessandra.balduini@tufts.edu

PY - 2019

Y1 - 2019

KW - fibronectin

KW - fibronectin eda

KW - immunoglobulin enhancer binding protein

KW - interleukin 6

KW - mitogen activated protein kinase 1

KW - mitogen activated protein kinase 3

KW - romiplostim

KW - STAT5 protein

KW - thrombopoietin

KW - toll like receptor 4

KW - unclassified drug

KW - animal experiment

KW - animal model

KW - Article

KW - cell differentiation

KW - cell expansion

KW - cell proliferation

KW - controlled study

KW - enzyme linked immunosorbent assay

KW - exon

KW - extramedullary hematopoiesis

KW - hematopoietic tissue

KW - human

KW - inflammation

KW - megakaryocyte

KW - megakaryopoiesis

KW - mouse

KW - myelofibrosis

KW - nonhuman

KW - phenotype

KW - priority journal

KW - second cervical vertebra

KW - signal transduction

KW - splenomegaly

KW - stem cell

U2 - 10.1084/jem.20181074

DO - 10.1084/jem.20181074

M3 - Article

VL - 216

SP - 587

EP - 604

JO - Journal of Experimental Medicine

JF - Journal of Experimental Medicine

SN - 0022-1007

IS - 3

ER -

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EDA fibronectin–TLR4 axis sustains megakaryocyte expansion and inflammation in bone marrow fibrosis

Keywords

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MAGGIORE - EMERGENZA-URGENZA NELLE GRANDI CRONICITA'