"Edge-to-edge" repair for anterior mitral leaflet prolapse

Ottavio Alfieri, Michele De Bonis, Elisabetta Lapenna, Tommaso Regesta, Francesco Maisano, Lucia Torracca, Giovanni La Canna

Research output: Contribution to journalArticlepeer-review


The aim of this study is to report our results in a series of 150 consecutive patients (mean age 53 ± 15.4 years) in whom mitral regurgitation (MR) due to isolated anterior mitral leaflet (AML) prolapse was corrected using the edge-to-edge (E to E) technique over a period of more than 10 years. At admission, 49 (32.6%) patients were in NYHA class I, 46 (30.6%) in II, 51 (34%) in III and 4 (2.6%) in IV. In the great majority of the cases (111 patients, 74%), degenerative disease was the cause of MR. Hospital mortality was 0.6% (1/150). There were 7 late deaths. The actuarial overall survival and freedom from reoperation at 9 years were 91.6% ± 3.16% and 96.6% ± 1.74%, respectively. At follow-up (4.5 ± 3.21 years, range 2 months-12 years), the mean mitral valve area was 2.7 ± 0.5 cm2 and mitral regurgitation was absent or mild in 132 patients (88%). The results of this study demonstrate the effectiveness and durability of the E to E repair in the setting of AML prolapse. In our institution, this technique, in conjunction with annuloplasty, remains the method of choice to correct segmental prolapse of the AML.

Original languageEnglish
Pages (from-to)182-187
Number of pages6
JournalSeminars in Thoracic and Cardiovascular Surgery
Issue number2
Publication statusPublished - Jun 2004


  • Anterior mitral leaflet prolapse
  • Edge-to-edge technique
  • Mitral repair

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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