Abstract
According to the reserve hypothesis, a high educational/occupational attainment can modulate Alzheimer's disease (AD) clinical expression. The impact of the Apolipoprotein E (ApoE) ε4 allele on the reserve mechanism in AD has not been assessed. Aim of this European multicenter study was to evaluate the metabolic correlates of reserve and ApoE genotype in early probable AD. 51 AD subjects, 27 ε4 carriers, and 24 noncarriers, underwent FDG-PET brain imaging. We used the general linear model as implemented in SPM2 to test for the linear correlation of a reserve index, accounting for both educational and occupational level, with brain glucose metabolism, controlling for demographic variables (age and gender) and for cognitive performance. We found an inverse correlation between a reserve index, accounting for educational/occupational level, and metabolism in the posterior cingulate cortex and precuneus in both ε4 carriers and noncarriers, and no significant difference between the groups. We show that education and occupation act as proxies for reserve in ε4 carriers, compensating for an unfavorable genetic background; we also show that the degree of compensation does not differ significantly by ApoE ε4 status.
| Original language | English |
|---|---|
| Pages (from-to) | 1037-1042 |
| Number of pages | 6 |
| Journal | Neurological Sciences |
| Volume | 33 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Oct 2012 |
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Keywords
- Alzheimer's disease
- ApoE
- Education
- Glucose metabolism
- PET
ASJC Scopus subject areas
- Clinical Neurology
- Psychiatry and Mental health
- Dermatology
Cite this
Education and occupation provide reserve in both ApoE ε4 carrier and noncarrier patients with probable alzheimer's disease. / Garibotto, V.; Borroni, B.; Sorbi, S.; Cappa, S. F.; Padovani, A.; Perani, D.
In: Neurological Sciences, Vol. 33, No. 5, 10.2012, p. 1037-1042.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Education and occupation provide reserve in both ApoE ε4 carrier and noncarrier patients with probable alzheimer's disease
AU - Garibotto, V.
AU - Borroni, B.
AU - Sorbi, S.
AU - Cappa, S. F.
AU - Padovani, A.
AU - Perani, D.
PY - 2012/10
Y1 - 2012/10
N2 - According to the reserve hypothesis, a high educational/occupational attainment can modulate Alzheimer's disease (AD) clinical expression. The impact of the Apolipoprotein E (ApoE) ε4 allele on the reserve mechanism in AD has not been assessed. Aim of this European multicenter study was to evaluate the metabolic correlates of reserve and ApoE genotype in early probable AD. 51 AD subjects, 27 ε4 carriers, and 24 noncarriers, underwent FDG-PET brain imaging. We used the general linear model as implemented in SPM2 to test for the linear correlation of a reserve index, accounting for both educational and occupational level, with brain glucose metabolism, controlling for demographic variables (age and gender) and for cognitive performance. We found an inverse correlation between a reserve index, accounting for educational/occupational level, and metabolism in the posterior cingulate cortex and precuneus in both ε4 carriers and noncarriers, and no significant difference between the groups. We show that education and occupation act as proxies for reserve in ε4 carriers, compensating for an unfavorable genetic background; we also show that the degree of compensation does not differ significantly by ApoE ε4 status.
AB - According to the reserve hypothesis, a high educational/occupational attainment can modulate Alzheimer's disease (AD) clinical expression. The impact of the Apolipoprotein E (ApoE) ε4 allele on the reserve mechanism in AD has not been assessed. Aim of this European multicenter study was to evaluate the metabolic correlates of reserve and ApoE genotype in early probable AD. 51 AD subjects, 27 ε4 carriers, and 24 noncarriers, underwent FDG-PET brain imaging. We used the general linear model as implemented in SPM2 to test for the linear correlation of a reserve index, accounting for both educational and occupational level, with brain glucose metabolism, controlling for demographic variables (age and gender) and for cognitive performance. We found an inverse correlation between a reserve index, accounting for educational/occupational level, and metabolism in the posterior cingulate cortex and precuneus in both ε4 carriers and noncarriers, and no significant difference between the groups. We show that education and occupation act as proxies for reserve in ε4 carriers, compensating for an unfavorable genetic background; we also show that the degree of compensation does not differ significantly by ApoE ε4 status.
KW - Alzheimer's disease
KW - ApoE
KW - Education
KW - Glucose metabolism
KW - PET
UR - http://www.scopus.com/inward/record.url?scp=84869213622&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84869213622&partnerID=8YFLogxK
U2 - 10.1007/s10072-011-0889-5
DO - 10.1007/s10072-011-0889-5
M3 - Article
C2 - 22173784
AN - SCOPUS:84869213622
VL - 33
SP - 1037
EP - 1042
JO - Neurological Sciences
JF - Neurological Sciences
SN - 1590-1874
IS - 5
ER -