Education modulates brain maintenance in presymptomatic frontotemporal dementia

Stefano Gazzina, Mario Grassi, Enrico Premi, Maura Cosseddu, Antonella Alberici, Silvana Archetti, Roberto Gasparotti, John Van Swieten, Daniela Galimberti, Raquel Sanchez-Valle, Robert Jr Laforce, Fermin Moreno, Matthis Synofzik, Caroline Graff, Mario Masellis, Maria Carmela Tartaglia, James B. Rowe, Rik Vandenberghe, Elizabeth Finger, Fabrizio TagliaviniAlexandre De Mendonça, Isabel Santana, Christopher R. Butler, Simon Ducharme, Alex Gerhard, Adrian Danek, Johannes Levin, Markus Otto, Giovanni Frisoni, Sandro Sorbi, Alessandro Padovani, Jonathan D. Rohrer, Barbara Borroni

Research output: Contribution to journalArticle

Abstract

Objective: Cognitively engaging lifestyles have been associated with reduced risk of conversion to dementia. Multiple mechanisms have been advocated, including increased brain volumes (ie, brain reserve) and reduced disease progression (ie, brain maintenance). In cross-sectional studies of presymptomatic frontotemporal dementia (FTD), higher education has been related to increased grey matter volume. Here, we examine the effect of education on grey matter loss over time. Methods: Two-hundred twenty-nine subjects at-risk of carrying a pathogenic mutation leading to FTD underwent longitudinal cognitive assessment and T1-weighted MRI at baseline and at 1 year follow-up. The first principal component score of the graph-Laplacian Principal Component Analysis on 112 grey matter region-of-interest volumes was used to summarise the grey matter volume (GMV). The effects of education on cognitive performances and GMV at baseline and on the change between 1 year follow-up and baseline (slope) were tested by Structural Equation Modelling. Results: Highly educated at-risk subjects had better cognition and higher grey matter volume at baseline; moreover, higher educational attainment was associated with slower loss of grey matter over time in mutation carriers. Conclusions: This longitudinal study demonstrates that even in presence of ongoing pathological processes, education may facilitate both brain reserve and brain maintenance in the presymptomatic phase of genetic FTD.

Original languageEnglish
JournalJournal of Neurology, Neurosurgery and Psychiatry
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Frontotemporal Dementia
Maintenance
Education
Brain
Cognitive Reserve
Mutation
Pathologic Processes
Gray Matter
Principal Component Analysis
Cognition
Longitudinal Studies
Dementia
Disease Progression
Life Style
Cross-Sectional Studies

Keywords

  • brain maintenance
  • brain reserve
  • frontotemporal dementia (FTD)
  • graph theory
  • magnetic resonance imaging (MRI)

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Education modulates brain maintenance in presymptomatic frontotemporal dementia. / Gazzina, Stefano; Grassi, Mario; Premi, Enrico; Cosseddu, Maura; Alberici, Antonella; Archetti, Silvana; Gasparotti, Roberto; Van Swieten, John; Galimberti, Daniela; Sanchez-Valle, Raquel; Laforce, Robert Jr; Moreno, Fermin; Synofzik, Matthis; Graff, Caroline; Masellis, Mario; Tartaglia, Maria Carmela; Rowe, James B.; Vandenberghe, Rik; Finger, Elizabeth; Tagliavini, Fabrizio; De Mendonça, Alexandre; Santana, Isabel; Butler, Christopher R.; Ducharme, Simon; Gerhard, Alex; Danek, Adrian; Levin, Johannes; Otto, Markus; Frisoni, Giovanni; Sorbi, Sandro; Padovani, Alessandro; Rohrer, Jonathan D.; Borroni, Barbara.

In: Journal of Neurology, Neurosurgery and Psychiatry, 01.01.2019.

Research output: Contribution to journalArticle

Gazzina, S, Grassi, M, Premi, E, Cosseddu, M, Alberici, A, Archetti, S, Gasparotti, R, Van Swieten, J, Galimberti, D, Sanchez-Valle, R, Laforce, RJ, Moreno, F, Synofzik, M, Graff, C, Masellis, M, Tartaglia, MC, Rowe, JB, Vandenberghe, R, Finger, E, Tagliavini, F, De Mendonça, A, Santana, I, Butler, CR, Ducharme, S, Gerhard, A, Danek, A, Levin, J, Otto, M, Frisoni, G, Sorbi, S, Padovani, A, Rohrer, JD & Borroni, B 2019, 'Education modulates brain maintenance in presymptomatic frontotemporal dementia', Journal of Neurology, Neurosurgery and Psychiatry. https://doi.org/10.1136/jnnp-2019-320439
Gazzina, Stefano ; Grassi, Mario ; Premi, Enrico ; Cosseddu, Maura ; Alberici, Antonella ; Archetti, Silvana ; Gasparotti, Roberto ; Van Swieten, John ; Galimberti, Daniela ; Sanchez-Valle, Raquel ; Laforce, Robert Jr ; Moreno, Fermin ; Synofzik, Matthis ; Graff, Caroline ; Masellis, Mario ; Tartaglia, Maria Carmela ; Rowe, James B. ; Vandenberghe, Rik ; Finger, Elizabeth ; Tagliavini, Fabrizio ; De Mendonça, Alexandre ; Santana, Isabel ; Butler, Christopher R. ; Ducharme, Simon ; Gerhard, Alex ; Danek, Adrian ; Levin, Johannes ; Otto, Markus ; Frisoni, Giovanni ; Sorbi, Sandro ; Padovani, Alessandro ; Rohrer, Jonathan D. ; Borroni, Barbara. / Education modulates brain maintenance in presymptomatic frontotemporal dementia. In: Journal of Neurology, Neurosurgery and Psychiatry. 2019.
@article{90216ed037ba449abd5b850236d12ba8,
title = "Education modulates brain maintenance in presymptomatic frontotemporal dementia",
abstract = "Objective: Cognitively engaging lifestyles have been associated with reduced risk of conversion to dementia. Multiple mechanisms have been advocated, including increased brain volumes (ie, brain reserve) and reduced disease progression (ie, brain maintenance). In cross-sectional studies of presymptomatic frontotemporal dementia (FTD), higher education has been related to increased grey matter volume. Here, we examine the effect of education on grey matter loss over time. Methods: Two-hundred twenty-nine subjects at-risk of carrying a pathogenic mutation leading to FTD underwent longitudinal cognitive assessment and T1-weighted MRI at baseline and at 1 year follow-up. The first principal component score of the graph-Laplacian Principal Component Analysis on 112 grey matter region-of-interest volumes was used to summarise the grey matter volume (GMV). The effects of education on cognitive performances and GMV at baseline and on the change between 1 year follow-up and baseline (slope) were tested by Structural Equation Modelling. Results: Highly educated at-risk subjects had better cognition and higher grey matter volume at baseline; moreover, higher educational attainment was associated with slower loss of grey matter over time in mutation carriers. Conclusions: This longitudinal study demonstrates that even in presence of ongoing pathological processes, education may facilitate both brain reserve and brain maintenance in the presymptomatic phase of genetic FTD.",
keywords = "brain maintenance, brain reserve, frontotemporal dementia (FTD), graph theory, magnetic resonance imaging (MRI)",
author = "Stefano Gazzina and Mario Grassi and Enrico Premi and Maura Cosseddu and Antonella Alberici and Silvana Archetti and Roberto Gasparotti and {Van Swieten}, John and Daniela Galimberti and Raquel Sanchez-Valle and Laforce, {Robert Jr} and Fermin Moreno and Matthis Synofzik and Caroline Graff and Mario Masellis and Tartaglia, {Maria Carmela} and Rowe, {James B.} and Rik Vandenberghe and Elizabeth Finger and Fabrizio Tagliavini and {De Mendon{\cc}a}, Alexandre and Isabel Santana and Butler, {Christopher R.} and Simon Ducharme and Alex Gerhard and Adrian Danek and Johannes Levin and Markus Otto and Giovanni Frisoni and Sandro Sorbi and Alessandro Padovani and Rohrer, {Jonathan D.} and Barbara Borroni",
year = "2019",
month = "1",
day = "1",
doi = "10.1136/jnnp-2019-320439",
language = "English",
journal = "Journal of Neurology, Neurosurgery and Psychiatry",
issn = "0022-3050",
publisher = "BMJ Publishing Group",

}

TY - JOUR

T1 - Education modulates brain maintenance in presymptomatic frontotemporal dementia

AU - Gazzina, Stefano

AU - Grassi, Mario

AU - Premi, Enrico

AU - Cosseddu, Maura

AU - Alberici, Antonella

AU - Archetti, Silvana

AU - Gasparotti, Roberto

AU - Van Swieten, John

AU - Galimberti, Daniela

AU - Sanchez-Valle, Raquel

AU - Laforce, Robert Jr

AU - Moreno, Fermin

AU - Synofzik, Matthis

AU - Graff, Caroline

AU - Masellis, Mario

AU - Tartaglia, Maria Carmela

AU - Rowe, James B.

AU - Vandenberghe, Rik

AU - Finger, Elizabeth

AU - Tagliavini, Fabrizio

AU - De Mendonça, Alexandre

AU - Santana, Isabel

AU - Butler, Christopher R.

AU - Ducharme, Simon

AU - Gerhard, Alex

AU - Danek, Adrian

AU - Levin, Johannes

AU - Otto, Markus

AU - Frisoni, Giovanni

AU - Sorbi, Sandro

AU - Padovani, Alessandro

AU - Rohrer, Jonathan D.

AU - Borroni, Barbara

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Objective: Cognitively engaging lifestyles have been associated with reduced risk of conversion to dementia. Multiple mechanisms have been advocated, including increased brain volumes (ie, brain reserve) and reduced disease progression (ie, brain maintenance). In cross-sectional studies of presymptomatic frontotemporal dementia (FTD), higher education has been related to increased grey matter volume. Here, we examine the effect of education on grey matter loss over time. Methods: Two-hundred twenty-nine subjects at-risk of carrying a pathogenic mutation leading to FTD underwent longitudinal cognitive assessment and T1-weighted MRI at baseline and at 1 year follow-up. The first principal component score of the graph-Laplacian Principal Component Analysis on 112 grey matter region-of-interest volumes was used to summarise the grey matter volume (GMV). The effects of education on cognitive performances and GMV at baseline and on the change between 1 year follow-up and baseline (slope) were tested by Structural Equation Modelling. Results: Highly educated at-risk subjects had better cognition and higher grey matter volume at baseline; moreover, higher educational attainment was associated with slower loss of grey matter over time in mutation carriers. Conclusions: This longitudinal study demonstrates that even in presence of ongoing pathological processes, education may facilitate both brain reserve and brain maintenance in the presymptomatic phase of genetic FTD.

AB - Objective: Cognitively engaging lifestyles have been associated with reduced risk of conversion to dementia. Multiple mechanisms have been advocated, including increased brain volumes (ie, brain reserve) and reduced disease progression (ie, brain maintenance). In cross-sectional studies of presymptomatic frontotemporal dementia (FTD), higher education has been related to increased grey matter volume. Here, we examine the effect of education on grey matter loss over time. Methods: Two-hundred twenty-nine subjects at-risk of carrying a pathogenic mutation leading to FTD underwent longitudinal cognitive assessment and T1-weighted MRI at baseline and at 1 year follow-up. The first principal component score of the graph-Laplacian Principal Component Analysis on 112 grey matter region-of-interest volumes was used to summarise the grey matter volume (GMV). The effects of education on cognitive performances and GMV at baseline and on the change between 1 year follow-up and baseline (slope) were tested by Structural Equation Modelling. Results: Highly educated at-risk subjects had better cognition and higher grey matter volume at baseline; moreover, higher educational attainment was associated with slower loss of grey matter over time in mutation carriers. Conclusions: This longitudinal study demonstrates that even in presence of ongoing pathological processes, education may facilitate both brain reserve and brain maintenance in the presymptomatic phase of genetic FTD.

KW - brain maintenance

KW - brain reserve

KW - frontotemporal dementia (FTD)

KW - graph theory

KW - magnetic resonance imaging (MRI)

UR - http://www.scopus.com/inward/record.url?scp=85068044715&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85068044715&partnerID=8YFLogxK

U2 - 10.1136/jnnp-2019-320439

DO - 10.1136/jnnp-2019-320439

M3 - Article

C2 - 31182509

AN - SCOPUS:85068044715

JO - Journal of Neurology, Neurosurgery and Psychiatry

JF - Journal of Neurology, Neurosurgery and Psychiatry

SN - 0022-3050

ER -