TY - CHAP
T1 - EEG changes are specifically associated with atrophy in amydala and hippocampus in subjects with mild cognitive impairment
AU - Moretti, Davide V.
AU - Zanetti, Orazio
AU - Binetti, Giuliano
AU - Frisoni, Giovanni B.
PY - 2011
Y1 - 2011
N2 - We evaluated the association between amygdalo-hippocampal complex (AHC) atrophy and two EEG markers of cognitive decline: increase of theta/gamma and increase of alpha3/alpha2 relative power ratio. Seventy-nine subjects with mild cognitive impairment (MCI) underwent EEG recording and MRI scan. Three groups of AHC growing atrophy were obtained. The groups were characterized by the performance to cognitive tests and theta/gamma and alpha3/alpha2 relative power ratio. AHC atrophy is associated with memory deficits as well as with increase of theta/gamma and alpha3/alpha2 ratio. Moreover, when the amygdalar and hippocampal volume are separately considered, within AHC, the increase of theta/gamma ratio is best associated with amygdalar atrophy whereas alpha3/alpha2 ratio is best associated with hippocampal atrophy. AHC atrophy is associated with memory deficits and EEG markers of cognitive decline. So far, these EEG markers could have a prospective value in differential diagnosis between MCI who will convert in in Alzheimer's disease (AD), MCI converting in non-AD dementias and MCI non-converters. The alterations of the functional connections, inducing global network pathological changes, in the whole AHC could better explain MCI state.
AB - We evaluated the association between amygdalo-hippocampal complex (AHC) atrophy and two EEG markers of cognitive decline: increase of theta/gamma and increase of alpha3/alpha2 relative power ratio. Seventy-nine subjects with mild cognitive impairment (MCI) underwent EEG recording and MRI scan. Three groups of AHC growing atrophy were obtained. The groups were characterized by the performance to cognitive tests and theta/gamma and alpha3/alpha2 relative power ratio. AHC atrophy is associated with memory deficits as well as with increase of theta/gamma and alpha3/alpha2 ratio. Moreover, when the amygdalar and hippocampal volume are separately considered, within AHC, the increase of theta/gamma ratio is best associated with amygdalar atrophy whereas alpha3/alpha2 ratio is best associated with hippocampal atrophy. AHC atrophy is associated with memory deficits and EEG markers of cognitive decline. So far, these EEG markers could have a prospective value in differential diagnosis between MCI who will convert in in Alzheimer's disease (AD), MCI converting in non-AD dementias and MCI non-converters. The alterations of the functional connections, inducing global network pathological changes, in the whole AHC could better explain MCI state.
KW - amygdalo-hippocampal complex
KW - cognitive tests
KW - electroencephalography
KW - gamma rhythm
KW - Mild cognitive impairment
KW - theta rhythm
UR - http://www.scopus.com/inward/record.url?scp=84865433505&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84865433505&partnerID=8YFLogxK
U2 - 10.3233/978-1-60750-793-2-379
DO - 10.3233/978-1-60750-793-2-379
M3 - Chapter
AN - SCOPUS:84865433505
SN - 9781607507925
VL - 2
T3 - Advances in Alzheimer's Disease
SP - 379
EP - 389
BT - Advances in Alzheimer's Disease
ER -