Abstract
The effects of carbamazepine (CBZ) on EEG backgrouund activity have been studied, at rest and during mental processes, in 18 epileptic patients suffering from focal epilepsy and starting antiepileptic treatment for the first time. The EEGs were recorded before and after CBZ therapy, at rest with eyes closed (EC), during blocking reaction (BR), fixation (FIX) and mental arithmetic (MA) tasks, and then evaluated by spectral analysis. All data underwent statistical evaluation utilizing the ANOVA and correlation coefficient. The following parameters were evaluated by spectral analysis. All data underwent statistical evaluation utilizing the ANOVA and correlation coefficient. The following parameters were evaluated: mean absolute and relative power and mean frequency. The results have shown that CBZ induced a significant increase of slow activity at rest with EC, which was represented by delta potentials, and was correlated with CBZ plasma levels, In evaluating the different cortical activation patterns, a decrease of the alpha reactivity was noted during BR and FIX, while a significant increase of beta activity was observed during the performance of all tasks. The rwelationship between the increased beta power, possibly reflecting an increase of cognitive activity for processing information, and the lack of a significant decrease of alpha activity are discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 729-733 |
| Number of pages | 5 |
| Journal | Italian Journal of Neurological Sciences |
| Volume | 13 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Dec 1992 |
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Keywords
- Carbamazepine
- computerized EEG
- focal epilepsy
- mental processes
ASJC Scopus subject areas
- Neuroscience(all)
- Clinical Neurology
Cite this
EEG changes induced by carbamazepine therapy at rest and during mental processes. / Marciani, M. G.; Gigli, G. L.; Maschio, M. C E; Stefani, N.; Stefanini, F.; Bernardi, G.
In: Italian Journal of Neurological Sciences, Vol. 13, No. 9, 12.1992, p. 729-733.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - EEG changes induced by carbamazepine therapy at rest and during mental processes
AU - Marciani, M. G.
AU - Gigli, G. L.
AU - Maschio, M. C E
AU - Stefani, N.
AU - Stefanini, F.
AU - Bernardi, G.
PY - 1992/12
Y1 - 1992/12
N2 - The effects of carbamazepine (CBZ) on EEG backgrouund activity have been studied, at rest and during mental processes, in 18 epileptic patients suffering from focal epilepsy and starting antiepileptic treatment for the first time. The EEGs were recorded before and after CBZ therapy, at rest with eyes closed (EC), during blocking reaction (BR), fixation (FIX) and mental arithmetic (MA) tasks, and then evaluated by spectral analysis. All data underwent statistical evaluation utilizing the ANOVA and correlation coefficient. The following parameters were evaluated by spectral analysis. All data underwent statistical evaluation utilizing the ANOVA and correlation coefficient. The following parameters were evaluated: mean absolute and relative power and mean frequency. The results have shown that CBZ induced a significant increase of slow activity at rest with EC, which was represented by delta potentials, and was correlated with CBZ plasma levels, In evaluating the different cortical activation patterns, a decrease of the alpha reactivity was noted during BR and FIX, while a significant increase of beta activity was observed during the performance of all tasks. The rwelationship between the increased beta power, possibly reflecting an increase of cognitive activity for processing information, and the lack of a significant decrease of alpha activity are discussed.
AB - The effects of carbamazepine (CBZ) on EEG backgrouund activity have been studied, at rest and during mental processes, in 18 epileptic patients suffering from focal epilepsy and starting antiepileptic treatment for the first time. The EEGs were recorded before and after CBZ therapy, at rest with eyes closed (EC), during blocking reaction (BR), fixation (FIX) and mental arithmetic (MA) tasks, and then evaluated by spectral analysis. All data underwent statistical evaluation utilizing the ANOVA and correlation coefficient. The following parameters were evaluated by spectral analysis. All data underwent statistical evaluation utilizing the ANOVA and correlation coefficient. The following parameters were evaluated: mean absolute and relative power and mean frequency. The results have shown that CBZ induced a significant increase of slow activity at rest with EC, which was represented by delta potentials, and was correlated with CBZ plasma levels, In evaluating the different cortical activation patterns, a decrease of the alpha reactivity was noted during BR and FIX, while a significant increase of beta activity was observed during the performance of all tasks. The rwelationship between the increased beta power, possibly reflecting an increase of cognitive activity for processing information, and the lack of a significant decrease of alpha activity are discussed.
KW - Carbamazepine
KW - computerized EEG
KW - focal epilepsy
KW - mental processes
UR - http://www.scopus.com/inward/record.url?scp=0027062717&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027062717&partnerID=8YFLogxK
U2 - 10.1007/BF02229157
DO - 10.1007/BF02229157
M3 - Article
VL - 13
SP - 729
EP - 733
JO - Italian Journal of Neurological Sciences
JF - Italian Journal of Neurological Sciences
SN - 0392-0461
IS - 9
ER -