EEG comparisons in early Alzheimer's disease, dementia with Lewy bodies and Parkinson's disease with dementia patients with a 2-year follow-up

Laura Bonanni, Astrid Thomas, Pietro Tiraboschi, Bernardo Perfetti, Sara Varanese, Marco Onofrj

Research output: Contribution to journalArticle


EEG abnormalities have been reported for both dementia with Lewy bodies (DLB) and Alzheimer's disease (AD). Although it has been suggested that variations in mean EEG frequency are greater in the former, the existence of meaningful differences remains controversial. No evidence is as yet available for Parkinson's disease with dementia (PDD). The aim of this study was to evaluate whether EEG abnormalities can discriminate between DLB, AD and PDD in the earliest stages of dementia and to do this 50 DLB, 50 AD and 40 PDD patients with slight cognitive impairment at first visit (MMSE ≥ 20) were studied. To improve clinical diagnostic accuracy, special emphasis was placed on identifying cognitive fluctuations and REM-sleep behaviour disorder. EEG variability was assessed by mean frequency analysis and compressed spectral arrays (CSA) in order to detect changes over time from different scalp derivations. Patients' initial diagnoses were revised at a 2-year follow-up visit with neuroimaging evaluation. Initial diagnoses were confirmed in 36 DLB, 40 AD and 35 PDD patients. The most relevant group differences were observed between the AD and DLB patients in EEGs from posterior derivations (P

Original languageEnglish
Pages (from-to)690-705
Number of pages16
Issue number3
Publication statusPublished - Mar 2008



  • Alzheimer's disease
  • Compressed spectral array
  • Dementia with Lewy Bodies
  • Parkinson's disease with dementia
  • Quantitative electroencephalography

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this