EEG-EMG information flow in movement-activated myoclonus in patients with Unverricht-Lundborg disease

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objective: We aimed the present study at estimating the appropriateness of generalised partial directed coherence (GPDC) in detecting myoclonus-related EEG-EMG connectivity pattern and the information flow between sensorimotor cortex and muscles in patients with typical cortical myoclonus due to Unverricht-Lundborg disease. Methods: In 13 patients with cortical myoclonus, we analysed the EEG and EMG signals recorded during simple voluntary motor activities using GPDC, a frequency domain linear index of connectivity estimated from a multivariate autoregressive model. The results were compared with those obtained in 12 healthy controls. Results: The GPDC revealed a peculiar pattern characterising patients with cortical myoclonus with respect to healthy subjects. Patients consistently had significant more robust outflow toward activated muscle originating from cortical areas exceeding the motor one. Moreover, they also had a more robust EMG outflow directed toward a wider cortical area contralateral to activated hand and sometimes also toward the ipsilateral central region. Conclusions: Our results clearly indicate the recruitment of extensive cortical network in afferent and efferent EEG-EMG relationships. Significance: Given that robust cortical outflow can be considered as the pathogenic mechanism sustaining myoclonus, the perturbation from the EMG outflow could lead to the involvement of large cortical area implied in sensorimotor integration and became capable of generating and maintaining the jerk recurrence.

Original languageEnglish
Pages (from-to)1803-1808
Number of pages6
JournalClinical Neurophysiology
Volume125
Issue number9
DOIs
Publication statusPublished - 2014

Fingerprint

Unverricht-Lundborg Syndrome
Myoclonus
Electroencephalography
Muscles
Motor Cortex
Healthy Volunteers
Motor Activity
Hand
Recurrence

Keywords

  • Cortical myoclonus
  • EEG
  • EPM1
  • GPDC
  • MVAR

ASJC Scopus subject areas

  • Neurology
  • Physiology (medical)
  • Sensory Systems
  • Clinical Neurology
  • Medicine(all)

Cite this

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title = "EEG-EMG information flow in movement-activated myoclonus in patients with Unverricht-Lundborg disease",
abstract = "Objective: We aimed the present study at estimating the appropriateness of generalised partial directed coherence (GPDC) in detecting myoclonus-related EEG-EMG connectivity pattern and the information flow between sensorimotor cortex and muscles in patients with typical cortical myoclonus due to Unverricht-Lundborg disease. Methods: In 13 patients with cortical myoclonus, we analysed the EEG and EMG signals recorded during simple voluntary motor activities using GPDC, a frequency domain linear index of connectivity estimated from a multivariate autoregressive model. The results were compared with those obtained in 12 healthy controls. Results: The GPDC revealed a peculiar pattern characterising patients with cortical myoclonus with respect to healthy subjects. Patients consistently had significant more robust outflow toward activated muscle originating from cortical areas exceeding the motor one. Moreover, they also had a more robust EMG outflow directed toward a wider cortical area contralateral to activated hand and sometimes also toward the ipsilateral central region. Conclusions: Our results clearly indicate the recruitment of extensive cortical network in afferent and efferent EEG-EMG relationships. Significance: Given that robust cortical outflow can be considered as the pathogenic mechanism sustaining myoclonus, the perturbation from the EMG outflow could lead to the involvement of large cortical area implied in sensorimotor integration and became capable of generating and maintaining the jerk recurrence.",
keywords = "Cortical myoclonus, EEG, EPM1, GPDC, MVAR",
author = "Ferruccio Panzica and Laura Canafoglia and Silvana Franceschetti",
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N2 - Objective: We aimed the present study at estimating the appropriateness of generalised partial directed coherence (GPDC) in detecting myoclonus-related EEG-EMG connectivity pattern and the information flow between sensorimotor cortex and muscles in patients with typical cortical myoclonus due to Unverricht-Lundborg disease. Methods: In 13 patients with cortical myoclonus, we analysed the EEG and EMG signals recorded during simple voluntary motor activities using GPDC, a frequency domain linear index of connectivity estimated from a multivariate autoregressive model. The results were compared with those obtained in 12 healthy controls. Results: The GPDC revealed a peculiar pattern characterising patients with cortical myoclonus with respect to healthy subjects. Patients consistently had significant more robust outflow toward activated muscle originating from cortical areas exceeding the motor one. Moreover, they also had a more robust EMG outflow directed toward a wider cortical area contralateral to activated hand and sometimes also toward the ipsilateral central region. Conclusions: Our results clearly indicate the recruitment of extensive cortical network in afferent and efferent EEG-EMG relationships. Significance: Given that robust cortical outflow can be considered as the pathogenic mechanism sustaining myoclonus, the perturbation from the EMG outflow could lead to the involvement of large cortical area implied in sensorimotor integration and became capable of generating and maintaining the jerk recurrence.

AB - Objective: We aimed the present study at estimating the appropriateness of generalised partial directed coherence (GPDC) in detecting myoclonus-related EEG-EMG connectivity pattern and the information flow between sensorimotor cortex and muscles in patients with typical cortical myoclonus due to Unverricht-Lundborg disease. Methods: In 13 patients with cortical myoclonus, we analysed the EEG and EMG signals recorded during simple voluntary motor activities using GPDC, a frequency domain linear index of connectivity estimated from a multivariate autoregressive model. The results were compared with those obtained in 12 healthy controls. Results: The GPDC revealed a peculiar pattern characterising patients with cortical myoclonus with respect to healthy subjects. Patients consistently had significant more robust outflow toward activated muscle originating from cortical areas exceeding the motor one. Moreover, they also had a more robust EMG outflow directed toward a wider cortical area contralateral to activated hand and sometimes also toward the ipsilateral central region. Conclusions: Our results clearly indicate the recruitment of extensive cortical network in afferent and efferent EEG-EMG relationships. Significance: Given that robust cortical outflow can be considered as the pathogenic mechanism sustaining myoclonus, the perturbation from the EMG outflow could lead to the involvement of large cortical area implied in sensorimotor integration and became capable of generating and maintaining the jerk recurrence.

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