EEG evidence of posterior cortical disconnection in PD and related dementias

Luigi Pugnetti, Francesca Baglio, Elisabetta Farina, Margherita Alberoni, Elena Calabrese, Antonio Gambini, Enrico Di Bella, Massimo Garegnani, Laura Deleonardis, Raffaello Nemni

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Electroencephalogram (EEG) reactivity to eyes opening and 12-Hz photic stimulation was investigated in 14 healthy elderly subjects, 21 parkinsonian patients (PD), 7 demented parkinsonian patients (PDD), and 10 patients with Lewy body dementia (LBD) using global field synchronization (GFS). During eyes closed Theta GFS was increased in Parkinson's disease and patients and alpha1 GFS was decreased in LBD subjects. During 12-Hz intermittent photic stimulation (IPS), reactivity of posterior electrodes was decreased in PD and LBD patients. No reactivity was observed in PDD. Results are consistent with a graded posterior cortical disconnection in parkinsonian syndromes and with a model of dopamine-modulated thalamocortical interplay in visual processing.

Original languageEnglish
Pages (from-to)88-98
Number of pages11
JournalInternational Journal of Neuroscience
Volume120
Issue number2
DOIs
Publication statusPublished - 2010

Fingerprint

Dementia
Electroencephalography
Lewy Body Disease
Photic Stimulation
Parkinsonian Disorders
Parkinson Disease
Dopamine
Healthy Volunteers
Electrodes

Keywords

  • Global field synchronization
  • LBD
  • PD
  • PDD
  • Photic stimulation
  • Quantitative EEG

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

EEG evidence of posterior cortical disconnection in PD and related dementias. / Pugnetti, Luigi; Baglio, Francesca; Farina, Elisabetta; Alberoni, Margherita; Calabrese, Elena; Gambini, Antonio; Di Bella, Enrico; Garegnani, Massimo; Deleonardis, Laura; Nemni, Raffaello.

In: International Journal of Neuroscience, Vol. 120, No. 2, 2010, p. 88-98.

Research output: Contribution to journalArticle

@article{207cfeec695942d8a4a41370ddfc606b,
title = "EEG evidence of posterior cortical disconnection in PD and related dementias",
abstract = "Electroencephalogram (EEG) reactivity to eyes opening and 12-Hz photic stimulation was investigated in 14 healthy elderly subjects, 21 parkinsonian patients (PD), 7 demented parkinsonian patients (PDD), and 10 patients with Lewy body dementia (LBD) using global field synchronization (GFS). During eyes closed Theta GFS was increased in Parkinson's disease and patients and alpha1 GFS was decreased in LBD subjects. During 12-Hz intermittent photic stimulation (IPS), reactivity of posterior electrodes was decreased in PD and LBD patients. No reactivity was observed in PDD. Results are consistent with a graded posterior cortical disconnection in parkinsonian syndromes and with a model of dopamine-modulated thalamocortical interplay in visual processing.",
keywords = "Global field synchronization, LBD, PD, PDD, Photic stimulation, Quantitative EEG",
author = "Luigi Pugnetti and Francesca Baglio and Elisabetta Farina and Margherita Alberoni and Elena Calabrese and Antonio Gambini and {Di Bella}, Enrico and Massimo Garegnani and Laura Deleonardis and Raffaello Nemni",
year = "2010",
doi = "10.3109/00207450903436346",
language = "English",
volume = "120",
pages = "88--98",
journal = "International Journal of Neuroscience",
issn = "0020-7454",
publisher = "Informa Healthcare",
number = "2",

}

TY - JOUR

T1 - EEG evidence of posterior cortical disconnection in PD and related dementias

AU - Pugnetti, Luigi

AU - Baglio, Francesca

AU - Farina, Elisabetta

AU - Alberoni, Margherita

AU - Calabrese, Elena

AU - Gambini, Antonio

AU - Di Bella, Enrico

AU - Garegnani, Massimo

AU - Deleonardis, Laura

AU - Nemni, Raffaello

PY - 2010

Y1 - 2010

N2 - Electroencephalogram (EEG) reactivity to eyes opening and 12-Hz photic stimulation was investigated in 14 healthy elderly subjects, 21 parkinsonian patients (PD), 7 demented parkinsonian patients (PDD), and 10 patients with Lewy body dementia (LBD) using global field synchronization (GFS). During eyes closed Theta GFS was increased in Parkinson's disease and patients and alpha1 GFS was decreased in LBD subjects. During 12-Hz intermittent photic stimulation (IPS), reactivity of posterior electrodes was decreased in PD and LBD patients. No reactivity was observed in PDD. Results are consistent with a graded posterior cortical disconnection in parkinsonian syndromes and with a model of dopamine-modulated thalamocortical interplay in visual processing.

AB - Electroencephalogram (EEG) reactivity to eyes opening and 12-Hz photic stimulation was investigated in 14 healthy elderly subjects, 21 parkinsonian patients (PD), 7 demented parkinsonian patients (PDD), and 10 patients with Lewy body dementia (LBD) using global field synchronization (GFS). During eyes closed Theta GFS was increased in Parkinson's disease and patients and alpha1 GFS was decreased in LBD subjects. During 12-Hz intermittent photic stimulation (IPS), reactivity of posterior electrodes was decreased in PD and LBD patients. No reactivity was observed in PDD. Results are consistent with a graded posterior cortical disconnection in parkinsonian syndromes and with a model of dopamine-modulated thalamocortical interplay in visual processing.

KW - Global field synchronization

KW - LBD

KW - PD

KW - PDD

KW - Photic stimulation

KW - Quantitative EEG

UR - http://www.scopus.com/inward/record.url?scp=77749246140&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77749246140&partnerID=8YFLogxK

U2 - 10.3109/00207450903436346

DO - 10.3109/00207450903436346

M3 - Article

C2 - 20199199

AN - SCOPUS:77749246140

VL - 120

SP - 88

EP - 98

JO - International Journal of Neuroscience

JF - International Journal of Neuroscience

SN - 0020-7454

IS - 2

ER -