EEG features and epilepsy in patients with autism

Paola Giovanardi Rossi, Antonia Parmeggiani, Véronique Bach, Margherita Santucci, Paola Visconti

Research output: Contribution to journalArticle

156 Citations (Scopus)

Abstract

Epileptic seizures are frequently reported (4-32%) in autism. These values are higher than in the normal population of children and adolescents (0.5%). In the literature there is no uniform description of epilepsy in autism. We examined 106 patients with autistic disorder divided into three groups on the basis of presence or absence of EEG paroxysmal abnormalities (PA) and/or epilepsy including febrile convulsions (FC). Our patients presented an autistic syndrome unrelated to clear congenital or acquired encephalopathy. The prevalence of epilepsy and EEG PA was 23.6% and 18.9%, respectively. Significant differences between the three groups appeared for (i) familial antecedents for epilepsy/FC and neurologic and psychiatric diseases (P <0.004), (ii) a different proportion between the three groups for mental retardation (P <0.03), (iii) and EEG fast activity (P <0.04). Our patients showed several types of epilepsy, including idiopathic forms with seizure onset after the age of 10 in 45% of cases. Seizures were mainly partial, not frequent and controllable by anti-epileptic drugs. PA were mostly focal and multifocal and in 45% of cases were typical of benign childhood partial epilepsy with centro-temporal spikes. The higher incidence of epilepsy and EEG PA is apparently not related to organic pre-, peri- and postnatal antecedents or cerebral lesions. On the contrary, genetic factors responsible for autism and epilepsy seem important in the genesis of these two disorders.

Original languageEnglish
Pages (from-to)169-174
Number of pages6
JournalBrain and Development
Volume17
Issue number3
DOIs
Publication statusPublished - May 1995

Fingerprint

Autistic Disorder
Electroencephalography
Epilepsy
Febrile Seizures
Seizures
Rolandic Epilepsy
Partial Epilepsy
Brain Diseases
Nervous System Diseases
Age of Onset
Intellectual Disability
Psychiatry
Incidence
Pharmaceutical Preparations
Population

Keywords

  • Autism
  • Autistic syndrome
  • Autistic-like condition
  • EEG abnormality
  • Epilepsy
  • Genetic factor
  • Mental retardation
  • Psychiatric disorder

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology
  • Neurology

Cite this

EEG features and epilepsy in patients with autism. / Rossi, Paola Giovanardi; Parmeggiani, Antonia; Bach, Véronique; Santucci, Margherita; Visconti, Paola.

In: Brain and Development, Vol. 17, No. 3, 05.1995, p. 169-174.

Research output: Contribution to journalArticle

Rossi, Paola Giovanardi ; Parmeggiani, Antonia ; Bach, Véronique ; Santucci, Margherita ; Visconti, Paola. / EEG features and epilepsy in patients with autism. In: Brain and Development. 1995 ; Vol. 17, No. 3. pp. 169-174.
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