EEG markers discriminate among different subgroup of patients with mild cognitive impairment

Research output: Contribution to journalArticlepeer-review


Aim of the study is to discriminate among participants with mild cognitive impairment through electroencephalography brain rhythms. A total of 79 participants with MCI were classified into 4 subgroups based on the beginning of memory complaints up to the time of first visit. All participants underwent electroencephalography recording, magnetic resonance imaging, apolipoprotein E characterization, and volumetric morphometry estimation of hippocampal region. Electroencephalography markers show 2 distinct patterns: (1) increase of theta/ delta power ratio and highest value of alpha2 band power in the group with shorter duration of disease, the greater right-left hippocampal volume difference and worst memory performance; (2) the highest value of alpha3 band power and the highest alpha3/alpha2 power ratio in the group with the lesser total hippocampal volume but preserved memory performance. Apolipoprotein E4 is linked to a major risk of early beginning of disease. Electroencephalography markers allow a mean correct percentage of correct classification up to 89%.

Original languageEnglish
Pages (from-to)58-73
Number of pages16
JournalAmerican Journal of Alzheimer's Disease and other Dementias
Issue number1
Publication statusPublished - Feb 2010


  • Alpha rhythm
  • Alzheimer's disease
  • Apolipoprotein E
  • Cognitive tests
  • Electroencephalography
  • Mild cognitive impairment
  • Theta rhythm

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology


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