EEG markers discriminate among different subgroup of patients with mild cognitive impairment

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21 Citations (Scopus)

Abstract

Aim of the study is to discriminate among participants with mild cognitive impairment through electroencephalography brain rhythms. A total of 79 participants with MCI were classified into 4 subgroups based on the beginning of memory complaints up to the time of first visit. All participants underwent electroencephalography recording, magnetic resonance imaging, apolipoprotein E characterization, and volumetric morphometry estimation of hippocampal region. Electroencephalography markers show 2 distinct patterns: (1) increase of theta/ delta power ratio and highest value of alpha2 band power in the group with shorter duration of disease, the greater right-left hippocampal volume difference and worst memory performance; (2) the highest value of alpha3 band power and the highest alpha3/alpha2 power ratio in the group with the lesser total hippocampal volume but preserved memory performance. Apolipoprotein E4 is linked to a major risk of early beginning of disease. Electroencephalography markers allow a mean correct percentage of correct classification up to 89%.

Original languageEnglish
Pages (from-to)58-73
Number of pages16
JournalAmerican Journal of Alzheimer's Disease and other Dementias
Volume25
Issue number1
DOIs
Publication statusPublished - Feb 2010

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Electroencephalography
Apolipoprotein E4
Apolipoproteins E
Magnetic Resonance Imaging
Power (Psychology)
Cognitive Dysfunction
Brain

Keywords

  • Alpha rhythm
  • Alzheimer's disease
  • Apolipoprotein E
  • Cognitive tests
  • Electroencephalography
  • Mild cognitive impairment
  • Theta rhythm

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

Cite this

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title = "EEG markers discriminate among different subgroup of patients with mild cognitive impairment",
abstract = "Aim of the study is to discriminate among participants with mild cognitive impairment through electroencephalography brain rhythms. A total of 79 participants with MCI were classified into 4 subgroups based on the beginning of memory complaints up to the time of first visit. All participants underwent electroencephalography recording, magnetic resonance imaging, apolipoprotein E characterization, and volumetric morphometry estimation of hippocampal region. Electroencephalography markers show 2 distinct patterns: (1) increase of theta/ delta power ratio and highest value of alpha2 band power in the group with shorter duration of disease, the greater right-left hippocampal volume difference and worst memory performance; (2) the highest value of alpha3 band power and the highest alpha3/alpha2 power ratio in the group with the lesser total hippocampal volume but preserved memory performance. Apolipoprotein E4 is linked to a major risk of early beginning of disease. Electroencephalography markers allow a mean correct percentage of correct classification up to 89{\%}.",
keywords = "Alpha rhythm, Alzheimer's disease, Apolipoprotein E, Cognitive tests, Electroencephalography, Mild cognitive impairment, Theta rhythm",
author = "Moretti, {Vito Davide} and M. Pievani and C. Geroldi and G. Binetti and O. Zanetti and Rossini, {P. M.} and Frisoni, {G. B.}",
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AU - Moretti, Vito Davide

AU - Pievani, M.

AU - Geroldi, C.

AU - Binetti, G.

AU - Zanetti, O.

AU - Rossini, P. M.

AU - Frisoni, G. B.

PY - 2010/2

Y1 - 2010/2

N2 - Aim of the study is to discriminate among participants with mild cognitive impairment through electroencephalography brain rhythms. A total of 79 participants with MCI were classified into 4 subgroups based on the beginning of memory complaints up to the time of first visit. All participants underwent electroencephalography recording, magnetic resonance imaging, apolipoprotein E characterization, and volumetric morphometry estimation of hippocampal region. Electroencephalography markers show 2 distinct patterns: (1) increase of theta/ delta power ratio and highest value of alpha2 band power in the group with shorter duration of disease, the greater right-left hippocampal volume difference and worst memory performance; (2) the highest value of alpha3 band power and the highest alpha3/alpha2 power ratio in the group with the lesser total hippocampal volume but preserved memory performance. Apolipoprotein E4 is linked to a major risk of early beginning of disease. Electroencephalography markers allow a mean correct percentage of correct classification up to 89%.

AB - Aim of the study is to discriminate among participants with mild cognitive impairment through electroencephalography brain rhythms. A total of 79 participants with MCI were classified into 4 subgroups based on the beginning of memory complaints up to the time of first visit. All participants underwent electroencephalography recording, magnetic resonance imaging, apolipoprotein E characterization, and volumetric morphometry estimation of hippocampal region. Electroencephalography markers show 2 distinct patterns: (1) increase of theta/ delta power ratio and highest value of alpha2 band power in the group with shorter duration of disease, the greater right-left hippocampal volume difference and worst memory performance; (2) the highest value of alpha3 band power and the highest alpha3/alpha2 power ratio in the group with the lesser total hippocampal volume but preserved memory performance. Apolipoprotein E4 is linked to a major risk of early beginning of disease. Electroencephalography markers allow a mean correct percentage of correct classification up to 89%.

KW - Alpha rhythm

KW - Alzheimer's disease

KW - Apolipoprotein E

KW - Cognitive tests

KW - Electroencephalography

KW - Mild cognitive impairment

KW - Theta rhythm

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