In Congenital Hypothyroidsm (CH), despite early treatment some children develop neurological and intellectual deficits at later ages. We studied the EEG parameter modifications in 40 CH children: 18 of these patients (14 females, 4 males, age ranged between 6-18 years) were diagnosed clinically and further confirmed by measurements of serum T4, T3, TSH (group A) while 22 subjects ( 18 females, 4 males age ranged between 6 and 13 yrs) were detected by a screening program (group B). 20 Children matched for age, sex and socioeconomic state constituted the control group. The groups A and B were also subdivided in two groups according to age (group A: 9 subjects with age range between 10-14 yrs, 9 with age range between 14-18 yrs; group B: 15 with age included between 6 and 8 yrs and 11 with age ranged between 9-13 yrs. All patients were submitted to 10 minutes of EEG at rest, eyes closed. We considered the following parameters: absolute and relative power and coherence of delta (0.4-3.9 Hz), theta (4-7.9 Hz), alpha (8-11.9 Hz) and beta (12-30 Hz) frequency bands. Alterations of EEG parameters were present in both groups but especially in the young population of group A where we found significant modifications of absolute power and coherence of theta frequency band. We will discuss the importance of coherence modifications particularly in the Central Nervous System maturative development.
|Number of pages||1|
|Journal||Italian Journal of Neurological Sciences|
|Publication status||Published - 1997|
ASJC Scopus subject areas
- Clinical Neurology