EEG modifications in children with congenital hypothyroidism

C. Fomara, T. Locatelli, S. Medaglini, L. Leocani, G. Weber, L. Prina Cerai, G. Chiumello, G. Comi

Research output: Contribution to journalArticlepeer-review

Abstract

In Congenital Hypothyroidsm (CH), despite early treatment some children develop neurological and intellectual deficits at later ages. We studied the EEG parameter modifications in 40 CH children: 18 of these patients (14 females, 4 males, age ranged between 6-18 years) were diagnosed clinically and further confirmed by measurements of serum T4, T3, TSH (group A) while 22 subjects ( 18 females, 4 males age ranged between 6 and 13 yrs) were detected by a screening program (group B). 20 Children matched for age, sex and socioeconomic state constituted the control group. The groups A and B were also subdivided in two groups according to age (group A: 9 subjects with age range between 10-14 yrs, 9 with age range between 14-18 yrs; group B: 15 with age included between 6 and 8 yrs and 11 with age ranged between 9-13 yrs. All patients were submitted to 10 minutes of EEG at rest, eyes closed. We considered the following parameters: absolute and relative power and coherence of delta (0.4-3.9 Hz), theta (4-7.9 Hz), alpha (8-11.9 Hz) and beta (12-30 Hz) frequency bands. Alterations of EEG parameters were present in both groups but especially in the young population of group A where we found significant modifications of absolute power and coherence of theta frequency band. We will discuss the importance of coherence modifications particularly in the Central Nervous System maturative development.

Original languageEnglish
Pages (from-to)141
Number of pages1
JournalItalian Journal of Neurological Sciences
Volume18
Issue number4
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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