Efcects of guanethidine on histamine release during reflex vasodilatation in the dog

M. Condorelli, G. Rasetti, F. Rengo

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of guanethidine pretreatment on the release of [14C] histamine during the reflex vasodilatation induced in the atropinized gracilis muscle by rapid intravenous administration of noradrenaline, were studied in dogs. After guanethidine treatment the hemodynamic reflex response was completely abolished and no appreciable modification of [14C] histamine release from the gracilis muscle following intravenous noradrenaline was observed. These results suggest the hypothesis that the withdrawal of the sympathetic discharge represents the mechanism of histamine release during the reflex vasodilatation. Therefore, guanethidine would suppress both the passive and the histaminergic component of the baroreceptor reflex through the abolition of the sympathetic tone.

Original languageEnglish
Pages (from-to)379-384
Number of pages6
JournalBritish Journal of Pharmacology
Volume60
Issue number3
Publication statusPublished - 1977

ASJC Scopus subject areas

  • Pharmacology

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