Effect of α-lipoic acid on platelet reactivity in type 1 diabetic patients

Roberto Mollo, Francesco Zaccardi, Giancarla Scalone, Giuseppe Scavone, Paola Rizzo, Eliano Pio Navarese, Andrea Manto, Dario Pitocco, Gaetano Antonio Lanza, Giovanni Ghirlanda, Filippo Crea

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

OBJECTIVE - Type 1 diabetes is associated with increased platelet reactivity. We investigated whether α-lipoic acid (ALA) has any effect on platelet reactivity in these patients. RESEARCH DESIGN AND METHODS - We randomly assigned 51 type 1 diabetic patients to ALA (600 mg once daily) or placebo for 5 weeks. Platelet reactivity was evaluated by the PFA-100 method and by measuring CD41 and CD62 platelet expression. C-reactive protein (CRP) and 8-iso-prostaglandin F2α serum levels also were measured. RESULTS - Baseline variables were similar in the two groups. After treatment, closure time was longer (P = 0.006) and CD62P platelet expression was lower, both before (P = 0.002) and after (P = 0.009) ADP stimulation in the ALA group compared with the placebo group. CRP and 8-isoprostaglandin F2α levels showed no differences between the two groups. CONCLUSIONS - Our data show that ALA reduces measures of platelet reactivity ex vivo in type 1 diabetic patients, independently of antioxidant or anti-inflammatory effects.

Original languageEnglish
Pages (from-to)196-197
Number of pages2
JournalDiabetes Care
Volume35
Issue number2
DOIs
Publication statusPublished - Feb 2012

Fingerprint

Thioctic Acid
Blood Platelets
C-Reactive Protein
Placebos
Dinoprost
Type 1 Diabetes Mellitus
Adenosine Diphosphate
Anti-Inflammatory Agents
Research Design
Antioxidants
Serum

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialised Nursing

Cite this

Mollo, R., Zaccardi, F., Scalone, G., Scavone, G., Rizzo, P., Navarese, E. P., ... Crea, F. (2012). Effect of α-lipoic acid on platelet reactivity in type 1 diabetic patients. Diabetes Care, 35(2), 196-197. https://doi.org/10.2337/dc11-1255

Effect of α-lipoic acid on platelet reactivity in type 1 diabetic patients. / Mollo, Roberto; Zaccardi, Francesco; Scalone, Giancarla; Scavone, Giuseppe; Rizzo, Paola; Navarese, Eliano Pio; Manto, Andrea; Pitocco, Dario; Lanza, Gaetano Antonio; Ghirlanda, Giovanni; Crea, Filippo.

In: Diabetes Care, Vol. 35, No. 2, 02.2012, p. 196-197.

Research output: Contribution to journalArticle

Mollo, R, Zaccardi, F, Scalone, G, Scavone, G, Rizzo, P, Navarese, EP, Manto, A, Pitocco, D, Lanza, GA, Ghirlanda, G & Crea, F 2012, 'Effect of α-lipoic acid on platelet reactivity in type 1 diabetic patients', Diabetes Care, vol. 35, no. 2, pp. 196-197. https://doi.org/10.2337/dc11-1255
Mollo R, Zaccardi F, Scalone G, Scavone G, Rizzo P, Navarese EP et al. Effect of α-lipoic acid on platelet reactivity in type 1 diabetic patients. Diabetes Care. 2012 Feb;35(2):196-197. https://doi.org/10.2337/dc11-1255
Mollo, Roberto ; Zaccardi, Francesco ; Scalone, Giancarla ; Scavone, Giuseppe ; Rizzo, Paola ; Navarese, Eliano Pio ; Manto, Andrea ; Pitocco, Dario ; Lanza, Gaetano Antonio ; Ghirlanda, Giovanni ; Crea, Filippo. / Effect of α-lipoic acid on platelet reactivity in type 1 diabetic patients. In: Diabetes Care. 2012 ; Vol. 35, No. 2. pp. 196-197.
@article{62636173a80f42e38c67171cb049d91f,
title = "Effect of α-lipoic acid on platelet reactivity in type 1 diabetic patients",
abstract = "OBJECTIVE - Type 1 diabetes is associated with increased platelet reactivity. We investigated whether α-lipoic acid (ALA) has any effect on platelet reactivity in these patients. RESEARCH DESIGN AND METHODS - We randomly assigned 51 type 1 diabetic patients to ALA (600 mg once daily) or placebo for 5 weeks. Platelet reactivity was evaluated by the PFA-100 method and by measuring CD41 and CD62 platelet expression. C-reactive protein (CRP) and 8-iso-prostaglandin F2α serum levels also were measured. RESULTS - Baseline variables were similar in the two groups. After treatment, closure time was longer (P = 0.006) and CD62P platelet expression was lower, both before (P = 0.002) and after (P = 0.009) ADP stimulation in the ALA group compared with the placebo group. CRP and 8-isoprostaglandin F2α levels showed no differences between the two groups. CONCLUSIONS - Our data show that ALA reduces measures of platelet reactivity ex vivo in type 1 diabetic patients, independently of antioxidant or anti-inflammatory effects.",
author = "Roberto Mollo and Francesco Zaccardi and Giancarla Scalone and Giuseppe Scavone and Paola Rizzo and Navarese, {Eliano Pio} and Andrea Manto and Dario Pitocco and Lanza, {Gaetano Antonio} and Giovanni Ghirlanda and Filippo Crea",
year = "2012",
month = "2",
doi = "10.2337/dc11-1255",
language = "English",
volume = "35",
pages = "196--197",
journal = "Diabetes Care",
issn = "1935-5548",
publisher = "American Diabetes Association Inc.",
number = "2",

}

TY - JOUR

T1 - Effect of α-lipoic acid on platelet reactivity in type 1 diabetic patients

AU - Mollo, Roberto

AU - Zaccardi, Francesco

AU - Scalone, Giancarla

AU - Scavone, Giuseppe

AU - Rizzo, Paola

AU - Navarese, Eliano Pio

AU - Manto, Andrea

AU - Pitocco, Dario

AU - Lanza, Gaetano Antonio

AU - Ghirlanda, Giovanni

AU - Crea, Filippo

PY - 2012/2

Y1 - 2012/2

N2 - OBJECTIVE - Type 1 diabetes is associated with increased platelet reactivity. We investigated whether α-lipoic acid (ALA) has any effect on platelet reactivity in these patients. RESEARCH DESIGN AND METHODS - We randomly assigned 51 type 1 diabetic patients to ALA (600 mg once daily) or placebo for 5 weeks. Platelet reactivity was evaluated by the PFA-100 method and by measuring CD41 and CD62 platelet expression. C-reactive protein (CRP) and 8-iso-prostaglandin F2α serum levels also were measured. RESULTS - Baseline variables were similar in the two groups. After treatment, closure time was longer (P = 0.006) and CD62P platelet expression was lower, both before (P = 0.002) and after (P = 0.009) ADP stimulation in the ALA group compared with the placebo group. CRP and 8-isoprostaglandin F2α levels showed no differences between the two groups. CONCLUSIONS - Our data show that ALA reduces measures of platelet reactivity ex vivo in type 1 diabetic patients, independently of antioxidant or anti-inflammatory effects.

AB - OBJECTIVE - Type 1 diabetes is associated with increased platelet reactivity. We investigated whether α-lipoic acid (ALA) has any effect on platelet reactivity in these patients. RESEARCH DESIGN AND METHODS - We randomly assigned 51 type 1 diabetic patients to ALA (600 mg once daily) or placebo for 5 weeks. Platelet reactivity was evaluated by the PFA-100 method and by measuring CD41 and CD62 platelet expression. C-reactive protein (CRP) and 8-iso-prostaglandin F2α serum levels also were measured. RESULTS - Baseline variables were similar in the two groups. After treatment, closure time was longer (P = 0.006) and CD62P platelet expression was lower, both before (P = 0.002) and after (P = 0.009) ADP stimulation in the ALA group compared with the placebo group. CRP and 8-isoprostaglandin F2α levels showed no differences between the two groups. CONCLUSIONS - Our data show that ALA reduces measures of platelet reactivity ex vivo in type 1 diabetic patients, independently of antioxidant or anti-inflammatory effects.

UR - http://www.scopus.com/inward/record.url?scp=84859052764&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84859052764&partnerID=8YFLogxK

U2 - 10.2337/dc11-1255

DO - 10.2337/dc11-1255

M3 - Article

C2 - 22228743

AN - SCOPUS:84859052764

VL - 35

SP - 196

EP - 197

JO - Diabetes Care

JF - Diabetes Care

SN - 1935-5548

IS - 2

ER -