Effect of αIFN on unaggressive immunoproliferative disorders

F. Frigeri, A. De Renzo, R. Marceno, P. Ruggeri, P. Musto, A. Andriani, P. Citarrella, F. Caronia, B. Rotoli

Research output: Contribution to journalArticlepeer-review


Backgronnd. α-IFN is reported to be an effective treatment for a number of lymphoproliferative diseases. Little information is available at present on its effect in unaggressive immunoproliferative disorders. Study design and results. In a prospective non randomized study, 57 patients with IgG or IgA MGUS, smouldering myeloma or stage I MM treated with α-IFN (3 MU 3 times a week for at least 6 months) were compared to 129 untreated similar patients. Four patients in the IFN group showed a monoclonal component reduction >50% versus none in the control group, and 25% of patients suffered disease progression (MC increase > 50% and/or osteolytic lesions) in the IFN group as compared to 18% in the control group. Conclusions. α-IFN administration at the dose used is ineffective for the majority of patients with slowly proliferating immunoproliferative disorders; only a small subgroup of them may benefit from such a treatment.

Original languageEnglish
Pages (from-to)35-39
Number of pages5
Issue number1
Publication statusPublished - 1995


  • indolent myeloma
  • interferon
  • monoclonal gammapathy
  • stage I multiple myeloma

ASJC Scopus subject areas

  • Hematology


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