Effect of β-lactam antibiotics on migration and bactericidal activity of human phagocytes

A. Fietta, F. Sacchi, C. Bersani, F. Grassi, P. Mangiarotti, G. G. Grassi

Research output: Contribution to journalArticle

Abstract

The effect of β-lactam antibiotics upon some functions of human phagocytes was examined. Penicillins (carbenicillin and piperacillin), thienamycin, and cephalosporins (cefotetan, ceftazidime, and moxalactam) had no effect on either the random or directional migration or on the bactericidal activity of neutrophils and monocytes against Staphylococcus aureus. On the contrary, cefoperazone at therapeutic levels was shown to inhibit neutrophil chemotaxis.

Original languageEnglish
Pages (from-to)930-931
Number of pages2
JournalAntimicrobial Agents and Chemotherapy
Volume23
Issue number6
Publication statusPublished - 1983

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Lactams
Phagocytes
Human Activities
Neutrophils
Cefotetan
Moxalactam
Anti-Bacterial Agents
Carbenicillin
Cefoperazone
Piperacillin
Ceftazidime
Chemotaxis
Cephalosporins
Penicillins
Staphylococcus aureus
Monocytes
Therapeutics
thienamycin

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Fietta, A., Sacchi, F., Bersani, C., Grassi, F., Mangiarotti, P., & Grassi, G. G. (1983). Effect of β-lactam antibiotics on migration and bactericidal activity of human phagocytes. Antimicrobial Agents and Chemotherapy, 23(6), 930-931.

Effect of β-lactam antibiotics on migration and bactericidal activity of human phagocytes. / Fietta, A.; Sacchi, F.; Bersani, C.; Grassi, F.; Mangiarotti, P.; Grassi, G. G.

In: Antimicrobial Agents and Chemotherapy, Vol. 23, No. 6, 1983, p. 930-931.

Research output: Contribution to journalArticle

Fietta, A, Sacchi, F, Bersani, C, Grassi, F, Mangiarotti, P & Grassi, GG 1983, 'Effect of β-lactam antibiotics on migration and bactericidal activity of human phagocytes', Antimicrobial Agents and Chemotherapy, vol. 23, no. 6, pp. 930-931.
Fietta A, Sacchi F, Bersani C, Grassi F, Mangiarotti P, Grassi GG. Effect of β-lactam antibiotics on migration and bactericidal activity of human phagocytes. Antimicrobial Agents and Chemotherapy. 1983;23(6):930-931.
Fietta, A. ; Sacchi, F. ; Bersani, C. ; Grassi, F. ; Mangiarotti, P. ; Grassi, G. G. / Effect of β-lactam antibiotics on migration and bactericidal activity of human phagocytes. In: Antimicrobial Agents and Chemotherapy. 1983 ; Vol. 23, No. 6. pp. 930-931.
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