Effect of 3, 5 dimethylpyrazole on blood free fatty acids and glucose

A. Rizzi; A. Jori; E. Veneroni; S. Garattini

Effect of 3, 5 dimethylpyrazole on blood free fatty acids and glucose

A. Rizzi, A. Jori, E. Veneroni, S. Garattini

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

3, 5 Dimethylpyrazole lowers plasma free fatty acids in fed and fasted rats as well as in rats exposed to cold, submitted to adrenalectomy or treated with noradrenaline, ACTH or chlorpromazine. The accumulation of liver triglycerides following cold exposure, ethanol administration or ACTH treatment is also inhibited by 3, 5 dimethylpyrazole. In contrast with the marked effect on lipid metabolism, 3, 5 dimethylpyrazole did not exhibit any major effect on normal level of blood glucose or on hyperglycemia induced by glucose load or chlorpromazine treatment.

Original language	English
Pages (from-to)	1371-1375
Number of pages	5
Journal	Life Sciences
Volume	3
Issue number	12
Publication status	Published - Dec 1964

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)
Pharmacology

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title = "Effect of 3, 5 dimethylpyrazole on blood free fatty acids and glucose",

abstract = "3, 5 Dimethylpyrazole lowers plasma free fatty acids in fed and fasted rats as well as in rats exposed to cold, submitted to adrenalectomy or treated with noradrenaline, ACTH or chlorpromazine. The accumulation of liver triglycerides following cold exposure, ethanol administration or ACTH treatment is also inhibited by 3, 5 dimethylpyrazole. In contrast with the marked effect on lipid metabolism, 3, 5 dimethylpyrazole did not exhibit any major effect on normal level of blood glucose or on hyperglycemia induced by glucose load or chlorpromazine treatment.",

author = "A. Rizzi and A. Jori and E. Veneroni and S. Garattini",

year = "1964",

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AU - Rizzi, A.

AU - Jori, A.

AU - Veneroni, E.

AU - Garattini, S.

PY - 1964/12

Y1 - 1964/12

N2 - 3, 5 Dimethylpyrazole lowers plasma free fatty acids in fed and fasted rats as well as in rats exposed to cold, submitted to adrenalectomy or treated with noradrenaline, ACTH or chlorpromazine. The accumulation of liver triglycerides following cold exposure, ethanol administration or ACTH treatment is also inhibited by 3, 5 dimethylpyrazole. In contrast with the marked effect on lipid metabolism, 3, 5 dimethylpyrazole did not exhibit any major effect on normal level of blood glucose or on hyperglycemia induced by glucose load or chlorpromazine treatment.

AB - 3, 5 Dimethylpyrazole lowers plasma free fatty acids in fed and fasted rats as well as in rats exposed to cold, submitted to adrenalectomy or treated with noradrenaline, ACTH or chlorpromazine. The accumulation of liver triglycerides following cold exposure, ethanol administration or ACTH treatment is also inhibited by 3, 5 dimethylpyrazole. In contrast with the marked effect on lipid metabolism, 3, 5 dimethylpyrazole did not exhibit any major effect on normal level of blood glucose or on hyperglycemia induced by glucose load or chlorpromazine treatment.

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