Effect of 5-HT1A-receptor functional polymorphism on Theory of Mind performances in schizophrenia

Marta Bosia, Simona Anselmetti, Margherita Bechi, Cristina Lorenzi, Adele Pirovano, Federica Cocchi, Mariachiara Buonocore, Placido Bramanti, Enrico Smeraldi, Roberto Cavallaro

Research output: Contribution to journalArticle

Abstract

Theory of Mind (ToM) abilities are known to be impaired in schizophrenia and data from functional brain imaging studies showed that ToM deficit is correlated to prefrontal cortex (PFC) dysfunction. Moreover, several lines of evidence suggest a critical role for dopaminergic-serotoninergic interactions at the PFC level. In this view, we aimed to analyse the specific effect of the -1019. C/G functional polymorphism of the serotonin 1A receptor (5-HT1A-R), involved in both serotonin and dopamine transmission regulation. A total of 118 clinically stabilised schizophrenia patients was assessed with a neuropsychological battery, including evaluation of IQ, verbal memory, attention and executive function and a ToM task; they also underwent 5-HT1A-R genotyping. We observed a significant effect of the 5-HT1A-R genotype on ToM performances, with the CC genotype performing significantly better. The finding suggests an effect of the 5-HT1A-R polymorphism on ToM cognitive performance in schizophrenia patients, probably through complex interactions between dopaminergic and serotoninergic systems, involved in mentalising.

Original languageEnglish
Pages (from-to)187-190
Number of pages4
JournalPsychiatry Research
Volume188
Issue number2
DOIs
Publication statusPublished - Jul 30 2011

Fingerprint

Theory of Mind
Receptor, Serotonin, 5-HT1A
Schizophrenia
Prefrontal Cortex
Genotype
Functional Neuroimaging
Aptitude
Executive Function
Dopamine
Serotonin

Keywords

  • Cognitive functions
  • Schizophrenia
  • Serotonin1A-receptor (5-HT1A-R)
  • Theory of Mind

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Effect of 5-HT1A-receptor functional polymorphism on Theory of Mind performances in schizophrenia. / Bosia, Marta; Anselmetti, Simona; Bechi, Margherita; Lorenzi, Cristina; Pirovano, Adele; Cocchi, Federica; Buonocore, Mariachiara; Bramanti, Placido; Smeraldi, Enrico; Cavallaro, Roberto.

In: Psychiatry Research, Vol. 188, No. 2, 30.07.2011, p. 187-190.

Research output: Contribution to journalArticle

Bosia, Marta ; Anselmetti, Simona ; Bechi, Margherita ; Lorenzi, Cristina ; Pirovano, Adele ; Cocchi, Federica ; Buonocore, Mariachiara ; Bramanti, Placido ; Smeraldi, Enrico ; Cavallaro, Roberto. / Effect of 5-HT1A-receptor functional polymorphism on Theory of Mind performances in schizophrenia. In: Psychiatry Research. 2011 ; Vol. 188, No. 2. pp. 187-190.
@article{bdbd93ceb9514a6c820056d88701ed9a,
title = "Effect of 5-HT1A-receptor functional polymorphism on Theory of Mind performances in schizophrenia",
abstract = "Theory of Mind (ToM) abilities are known to be impaired in schizophrenia and data from functional brain imaging studies showed that ToM deficit is correlated to prefrontal cortex (PFC) dysfunction. Moreover, several lines of evidence suggest a critical role for dopaminergic-serotoninergic interactions at the PFC level. In this view, we aimed to analyse the specific effect of the -1019. C/G functional polymorphism of the serotonin 1A receptor (5-HT1A-R), involved in both serotonin and dopamine transmission regulation. A total of 118 clinically stabilised schizophrenia patients was assessed with a neuropsychological battery, including evaluation of IQ, verbal memory, attention and executive function and a ToM task; they also underwent 5-HT1A-R genotyping. We observed a significant effect of the 5-HT1A-R genotype on ToM performances, with the CC genotype performing significantly better. The finding suggests an effect of the 5-HT1A-R polymorphism on ToM cognitive performance in schizophrenia patients, probably through complex interactions between dopaminergic and serotoninergic systems, involved in mentalising.",
keywords = "Cognitive functions, Schizophrenia, Serotonin1A-receptor (5-HT1A-R), Theory of Mind",
author = "Marta Bosia and Simona Anselmetti and Margherita Bechi and Cristina Lorenzi and Adele Pirovano and Federica Cocchi and Mariachiara Buonocore and Placido Bramanti and Enrico Smeraldi and Roberto Cavallaro",
year = "2011",
month = "7",
day = "30",
doi = "10.1016/j.psychres.2010.11.014",
language = "English",
volume = "188",
pages = "187--190",
journal = "Psychiatry Research",
issn = "0165-1781",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Effect of 5-HT1A-receptor functional polymorphism on Theory of Mind performances in schizophrenia

AU - Bosia, Marta

AU - Anselmetti, Simona

AU - Bechi, Margherita

AU - Lorenzi, Cristina

AU - Pirovano, Adele

AU - Cocchi, Federica

AU - Buonocore, Mariachiara

AU - Bramanti, Placido

AU - Smeraldi, Enrico

AU - Cavallaro, Roberto

PY - 2011/7/30

Y1 - 2011/7/30

N2 - Theory of Mind (ToM) abilities are known to be impaired in schizophrenia and data from functional brain imaging studies showed that ToM deficit is correlated to prefrontal cortex (PFC) dysfunction. Moreover, several lines of evidence suggest a critical role for dopaminergic-serotoninergic interactions at the PFC level. In this view, we aimed to analyse the specific effect of the -1019. C/G functional polymorphism of the serotonin 1A receptor (5-HT1A-R), involved in both serotonin and dopamine transmission regulation. A total of 118 clinically stabilised schizophrenia patients was assessed with a neuropsychological battery, including evaluation of IQ, verbal memory, attention and executive function and a ToM task; they also underwent 5-HT1A-R genotyping. We observed a significant effect of the 5-HT1A-R genotype on ToM performances, with the CC genotype performing significantly better. The finding suggests an effect of the 5-HT1A-R polymorphism on ToM cognitive performance in schizophrenia patients, probably through complex interactions between dopaminergic and serotoninergic systems, involved in mentalising.

AB - Theory of Mind (ToM) abilities are known to be impaired in schizophrenia and data from functional brain imaging studies showed that ToM deficit is correlated to prefrontal cortex (PFC) dysfunction. Moreover, several lines of evidence suggest a critical role for dopaminergic-serotoninergic interactions at the PFC level. In this view, we aimed to analyse the specific effect of the -1019. C/G functional polymorphism of the serotonin 1A receptor (5-HT1A-R), involved in both serotonin and dopamine transmission regulation. A total of 118 clinically stabilised schizophrenia patients was assessed with a neuropsychological battery, including evaluation of IQ, verbal memory, attention and executive function and a ToM task; they also underwent 5-HT1A-R genotyping. We observed a significant effect of the 5-HT1A-R genotype on ToM performances, with the CC genotype performing significantly better. The finding suggests an effect of the 5-HT1A-R polymorphism on ToM cognitive performance in schizophrenia patients, probably through complex interactions between dopaminergic and serotoninergic systems, involved in mentalising.

KW - Cognitive functions

KW - Schizophrenia

KW - Serotonin1A-receptor (5-HT1A-R)

KW - Theory of Mind

UR - http://www.scopus.com/inward/record.url?scp=79958274680&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79958274680&partnerID=8YFLogxK

U2 - 10.1016/j.psychres.2010.11.014

DO - 10.1016/j.psychres.2010.11.014

M3 - Article

C2 - 21194755

AN - SCOPUS:79958274680

VL - 188

SP - 187

EP - 190

JO - Psychiatry Research

JF - Psychiatry Research

SN - 0165-1781

IS - 2

ER -