Effect of 5-HT1A-receptor functional polymorphism on Theory of Mind performances in schizophrenia

Marta Bosia, Simona Anselmetti, Margherita Bechi, Cristina Lorenzi, Adele Pirovano, Federica Cocchi, Mariachiara Buonocore, Placido Bramanti, Enrico Smeraldi, Roberto Cavallaro

Research output: Contribution to journalArticlepeer-review


Theory of Mind (ToM) abilities are known to be impaired in schizophrenia and data from functional brain imaging studies showed that ToM deficit is correlated to prefrontal cortex (PFC) dysfunction. Moreover, several lines of evidence suggest a critical role for dopaminergic-serotoninergic interactions at the PFC level. In this view, we aimed to analyse the specific effect of the -1019. C/G functional polymorphism of the serotonin 1A receptor (5-HT1A-R), involved in both serotonin and dopamine transmission regulation. A total of 118 clinically stabilised schizophrenia patients was assessed with a neuropsychological battery, including evaluation of IQ, verbal memory, attention and executive function and a ToM task; they also underwent 5-HT1A-R genotyping. We observed a significant effect of the 5-HT1A-R genotype on ToM performances, with the CC genotype performing significantly better. The finding suggests an effect of the 5-HT1A-R polymorphism on ToM cognitive performance in schizophrenia patients, probably through complex interactions between dopaminergic and serotoninergic systems, involved in mentalising.

Original languageEnglish
Pages (from-to)187-190
Number of pages4
JournalPsychiatry Research
Issue number2
Publication statusPublished - Jul 30 2011


  • Cognitive functions
  • Schizophrenia
  • Serotonin1A-receptor (5-HT1A-R)
  • Theory of Mind

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


Dive into the research topics of 'Effect of 5-HT1A-receptor functional polymorphism on Theory of Mind performances in schizophrenia'. Together they form a unique fingerprint.

Cite this