Effetto di una supplementazione di calcio e vitamina D sul turnover osseo

Translated title of the contribution: Effect of a calcium and vitamin D supplementation on bone turnover

M. L. Bianchi, E. Galbiati, A. Dubini, S. Saraifoger, R. Cherubini, S. Ortolani

Research output: Contribution to journalArticlepeer-review


Background. To evaluate the effects of a modest calcium and vitamin D supplementation on the main parameters of bone turnover. Methods. 13 post-menopausal women with a low bone mass taking a daily supplement of calcium (285 mg) and vitamin D (120 UI) were studied. The following parameters were measured: (on serum) total and ionized calcium, phosphatemia, creatinine, parathyroid hormone (PTH), bone-specific alkaline phosphatase (BSAP), osteocalcin (OC), C-terminal telopeptide (CTx); (on urine) calcium, creatinine, N-terminal telopeptide (NTx). Results. Calcium serum levels, both ionized and total, and calcium urinary excretion were significantly increased after 3 months of supplementation. On the contrary, the serum levels of PTH and the bone reabsorption markers (serum CTx and urine NTx) showed a significant reduction. Serum phosphate levels and bone formation markers (BSAP and OC) did not show any relevant change. Conclusions. The study has shown that even a modest increase in the daily intake of calcium and vitamin D can determine a reduction of PTH levels and bone resorption indexes in post-menopausal women with a reduction of bone mass. These changes, if maintained in the long term, could help in controlling the increase of bone resorption that is often present in these patients.

Translated title of the contributionEffect of a calcium and vitamin D supplementation on bone turnover
Original languageItalian
Pages (from-to)237-241
Number of pages5
JournalGazzetta Medica Italiana Archivio per le Scienze Mediche
Issue number6
Publication statusPublished - Dec 2002

ASJC Scopus subject areas

  • Medicine(all)


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