Effect of a Comprehensive Intervention on Plasma BDNF in Patients with Alzheimer's Disease

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Abstract

A comprehensive intervention (CI) on patients with Alzheimer's disease was assessed by measuring plasmabrain-derived neurotrophic factor (pBDNF) and ADAS-Cog score (ADAS-Cogscore) before, immediately after (FU1), and 6 (FU2) and 24 months (FU3) after the CI. Baseline pBDNF was higher in patients with moderate AD (but not mild AD) than in healthy controls. At FU1, pBDNF and ADAS-Cogscore decreased significantly. At FU2 and FU3, patients' cognitive status worsened and pBDNF further increased versus baseline, suggesting that CI interruption may be a stress event that prevents return to homeostasis. CI exerted positive short-term effects, but more information is needed on long-term consequences.

Original languageEnglish
Pages (from-to)37-43
Number of pages7
JournalJournal of Alzheimer's Disease
Volume57
Issue number1
DOIs
Publication statusPublished - 2017

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Brain-Derived Neurotrophic Factor
Nerve Growth Factors
Alzheimer Disease
Homeostasis

Keywords

  • Alzheimer disease
  • brain-derived neurotrophic factor
  • comprehensive intervention
  • plasma
  • time

ASJC Scopus subject areas

  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

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title = "Effect of a Comprehensive Intervention on Plasma BDNF in Patients with Alzheimer's Disease",
abstract = "A comprehensive intervention (CI) on patients with Alzheimer's disease was assessed by measuring plasmabrain-derived neurotrophic factor (pBDNF) and ADAS-Cog score (ADAS-Cogscore) before, immediately after (FU1), and 6 (FU2) and 24 months (FU3) after the CI. Baseline pBDNF was higher in patients with moderate AD (but not mild AD) than in healthy controls. At FU1, pBDNF and ADAS-Cogscore decreased significantly. At FU2 and FU3, patients' cognitive status worsened and pBDNF further increased versus baseline, suggesting that CI interruption may be a stress event that prevents return to homeostasis. CI exerted positive short-term effects, but more information is needed on long-term consequences.",
keywords = "Alzheimer disease, brain-derived neurotrophic factor, comprehensive intervention, plasma, time",
author = "Marta Balietti and Cinzia Giuli and Patrizia Fattoretti and Paolo Fabbietti and Roberta Papa and Demetrio Postacchini and Fiorenzo Conti",
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T1 - Effect of a Comprehensive Intervention on Plasma BDNF in Patients with Alzheimer's Disease

AU - Balietti, Marta

AU - Giuli, Cinzia

AU - Fattoretti, Patrizia

AU - Fabbietti, Paolo

AU - Papa, Roberta

AU - Postacchini, Demetrio

AU - Conti, Fiorenzo

PY - 2017

Y1 - 2017

N2 - A comprehensive intervention (CI) on patients with Alzheimer's disease was assessed by measuring plasmabrain-derived neurotrophic factor (pBDNF) and ADAS-Cog score (ADAS-Cogscore) before, immediately after (FU1), and 6 (FU2) and 24 months (FU3) after the CI. Baseline pBDNF was higher in patients with moderate AD (but not mild AD) than in healthy controls. At FU1, pBDNF and ADAS-Cogscore decreased significantly. At FU2 and FU3, patients' cognitive status worsened and pBDNF further increased versus baseline, suggesting that CI interruption may be a stress event that prevents return to homeostasis. CI exerted positive short-term effects, but more information is needed on long-term consequences.

AB - A comprehensive intervention (CI) on patients with Alzheimer's disease was assessed by measuring plasmabrain-derived neurotrophic factor (pBDNF) and ADAS-Cog score (ADAS-Cogscore) before, immediately after (FU1), and 6 (FU2) and 24 months (FU3) after the CI. Baseline pBDNF was higher in patients with moderate AD (but not mild AD) than in healthy controls. At FU1, pBDNF and ADAS-Cogscore decreased significantly. At FU2 and FU3, patients' cognitive status worsened and pBDNF further increased versus baseline, suggesting that CI interruption may be a stress event that prevents return to homeostasis. CI exerted positive short-term effects, but more information is needed on long-term consequences.

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