Effect of a Comprehensive Intervention on Plasma BDNF in Patients with Alzheimer's Disease

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Abstract

A comprehensive intervention (CI) on patients with Alzheimer's disease was assessed by measuring plasmabrain-derived neurotrophic factor (pBDNF) and ADAS-Cog score (ADAS-Cogscore) before, immediately after (FU1), and 6 (FU2) and 24 months (FU3) after the CI. Baseline pBDNF was higher in patients with moderate AD (but not mild AD) than in healthy controls. At FU1, pBDNF and ADAS-Cogscore decreased significantly. At FU2 and FU3, patients' cognitive status worsened and pBDNF further increased versus baseline, suggesting that CI interruption may be a stress event that prevents return to homeostasis. CI exerted positive short-term effects, but more information is needed on long-term consequences.

Original languageEnglish
Pages (from-to)37-43
Number of pages7
JournalJournal of Alzheimer's Disease
Volume57
Issue number1
DOIs
Publication statusPublished - 2017

Keywords

  • Alzheimer disease
  • brain-derived neurotrophic factor
  • comprehensive intervention
  • plasma
  • time

ASJC Scopus subject areas

  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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