Effect of a contraceptive steroid combination on the "serum activation" of lipoprotein lipase in rats

A. Bizzi, M. T. Tacconi, E. Veneroni, M. Cini, S. Garattini

Research output: Contribution to journalArticle

Abstract

Our investigation on serum obtained from control rats and from rats treated with a steroid contraceptive drug (SCD) showed that serum from SCD treated rats had a lower activating capacity for lipoprotein lipase from rat epididymal adipose tissue. A similar result was observed when HDL apolipoproteins obtained from serum of these two groups of rats were tested against a lipoprotein lipase preparation. The data suggest a deficiency or an alteration of some serum cofactors (probably apolipoproteins of the C group). The observation that chylomicrons from SCD treated rats were slightly poorer substrate for lipoprotein lipase than those from control rats supports the hypothesis of a cofactor deficiency rather than a transfer of apolipoproteins from HDL to chylomicrons.

Original languageEnglish
Pages (from-to)795-797
Number of pages3
JournalBiochemical Pharmacology
Volume27
Issue number5
DOIs
Publication statusPublished - Mar 1 1978

ASJC Scopus subject areas

  • Pharmacology

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