Effect of a contraceptive steroid combination on the "serum activation" of lipoprotein lipase in rats

A. Bizzi, M. T. Tacconi, E. Veneroni, M. Cini, S. Garattini

Research output: Contribution to journalArticle

Abstract

Our investigation on serum obtained from control rats and from rats treated with a steroid contraceptive drug (SCD) showed that serum from SCD treated rats had a lower activating capacity for lipoprotein lipase from rat epididymal adipose tissue. A similar result was observed when HDL apolipoproteins obtained from serum of these two groups of rats were tested against a lipoprotein lipase preparation. The data suggest a deficiency or an alteration of some serum cofactors (probably apolipoproteins of the C group). The observation that chylomicrons from SCD treated rats were slightly poorer substrate for lipoprotein lipase than those from control rats supports the hypothesis of a cofactor deficiency rather than a transfer of apolipoproteins from HDL to chylomicrons.

Original languageEnglish
Pages (from-to)795-797
Number of pages3
JournalBiochemical Pharmacology
Volume27
Issue number5
DOIs
Publication statusPublished - Mar 1 1978

Fingerprint

Lipoprotein Lipase
Contraceptive Agents
Rats
Chemical activation
Steroids
Rat control
Chylomicrons
Serum
Apolipoproteins
Apolipoproteins C
Pharmaceutical Preparations
Tissue
Adipose Tissue
Substrates

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effect of a contraceptive steroid combination on the "serum activation" of lipoprotein lipase in rats. / Bizzi, A.; Tacconi, M. T.; Veneroni, E.; Cini, M.; Garattini, S.

In: Biochemical Pharmacology, Vol. 27, No. 5, 01.03.1978, p. 795-797.

Research output: Contribution to journalArticle

Bizzi, A. ; Tacconi, M. T. ; Veneroni, E. ; Cini, M. ; Garattini, S. / Effect of a contraceptive steroid combination on the "serum activation" of lipoprotein lipase in rats. In: Biochemical Pharmacology. 1978 ; Vol. 27, No. 5. pp. 795-797.
@article{f423b3afac514db0a667446bd6d14ac9,
title = "Effect of a contraceptive steroid combination on the {"}serum activation{"} of lipoprotein lipase in rats",
abstract = "Our investigation on serum obtained from control rats and from rats treated with a steroid contraceptive drug (SCD) showed that serum from SCD treated rats had a lower activating capacity for lipoprotein lipase from rat epididymal adipose tissue. A similar result was observed when HDL apolipoproteins obtained from serum of these two groups of rats were tested against a lipoprotein lipase preparation. The data suggest a deficiency or an alteration of some serum cofactors (probably apolipoproteins of the C group). The observation that chylomicrons from SCD treated rats were slightly poorer substrate for lipoprotein lipase than those from control rats supports the hypothesis of a cofactor deficiency rather than a transfer of apolipoproteins from HDL to chylomicrons.",
author = "A. Bizzi and Tacconi, {M. T.} and E. Veneroni and M. Cini and S. Garattini",
year = "1978",
month = "3",
day = "1",
doi = "10.1016/0006-2952(78)90523-3",
language = "English",
volume = "27",
pages = "795--797",
journal = "Biochemical Pharmacology",
issn = "0006-2952",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Effect of a contraceptive steroid combination on the "serum activation" of lipoprotein lipase in rats

AU - Bizzi, A.

AU - Tacconi, M. T.

AU - Veneroni, E.

AU - Cini, M.

AU - Garattini, S.

PY - 1978/3/1

Y1 - 1978/3/1

N2 - Our investigation on serum obtained from control rats and from rats treated with a steroid contraceptive drug (SCD) showed that serum from SCD treated rats had a lower activating capacity for lipoprotein lipase from rat epididymal adipose tissue. A similar result was observed when HDL apolipoproteins obtained from serum of these two groups of rats were tested against a lipoprotein lipase preparation. The data suggest a deficiency or an alteration of some serum cofactors (probably apolipoproteins of the C group). The observation that chylomicrons from SCD treated rats were slightly poorer substrate for lipoprotein lipase than those from control rats supports the hypothesis of a cofactor deficiency rather than a transfer of apolipoproteins from HDL to chylomicrons.

AB - Our investigation on serum obtained from control rats and from rats treated with a steroid contraceptive drug (SCD) showed that serum from SCD treated rats had a lower activating capacity for lipoprotein lipase from rat epididymal adipose tissue. A similar result was observed when HDL apolipoproteins obtained from serum of these two groups of rats were tested against a lipoprotein lipase preparation. The data suggest a deficiency or an alteration of some serum cofactors (probably apolipoproteins of the C group). The observation that chylomicrons from SCD treated rats were slightly poorer substrate for lipoprotein lipase than those from control rats supports the hypothesis of a cofactor deficiency rather than a transfer of apolipoproteins from HDL to chylomicrons.

UR - http://www.scopus.com/inward/record.url?scp=0018086168&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018086168&partnerID=8YFLogxK

U2 - 10.1016/0006-2952(78)90523-3

DO - 10.1016/0006-2952(78)90523-3

M3 - Article

VL - 27

SP - 795

EP - 797

JO - Biochemical Pharmacology

JF - Biochemical Pharmacology

SN - 0006-2952

IS - 5

ER -