Abstract
Our investigation on serum obtained from control rats and from rats treated with a steroid contraceptive drug (SCD) showed that serum from SCD treated rats had a lower activating capacity for lipoprotein lipase from rat epididymal adipose tissue. A similar result was observed when HDL apolipoproteins obtained from serum of these 2 groups of rats were tested against a lipoprotein lipase preparation. The data suggest a deficiency or an alteration of some serum cofactors (probably apolipoproteins of the C group). The observation that chylomicrons from SCD treated rats were slightly poorer substrate for lipoprotein lipase than those from control rats supports the hypothesis of a cofactor deficiency rather than a transfer of apolipoproteins from HDL to chylomicrons.
Original language | English |
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Pages (from-to) | 795-797 |
Number of pages | 3 |
Journal | Biochemical Pharmacology |
Volume | 27 |
Issue number | 5 |
DOIs | |
Publication status | Published - 1978 |
ASJC Scopus subject areas
- Pharmacology