Effect of a contraceptive steroid combination on the 'serum activation' of lipoprotein lipase in rats

A. Bizzi; M. T. Tacconi; E. Veneroni; M. Cini; S. Garattini

doi:10.1016/0378-4274(77)90031-5

Effect of a contraceptive steroid combination on the 'serum activation' of lipoprotein lipase in rats

A. Bizzi, M. T. Tacconi, E. Veneroni, M. Cini, S. Garattini

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

Our investigation on serum obtained from control rats and from rats treated with a steroid contraceptive drug (SCD) showed that serum from SCD treated rats had a lower activating capacity for lipoprotein lipase from rat epididymal adipose tissue. A similar result was observed when HDL apolipoproteins obtained from serum of these 2 groups of rats were tested against a lipoprotein lipase preparation. The data suggest a deficiency or an alteration of some serum cofactors (probably apolipoproteins of the C group). The observation that chylomicrons from SCD treated rats were slightly poorer substrate for lipoprotein lipase than those from control rats supports the hypothesis of a cofactor deficiency rather than a transfer of apolipoproteins from HDL to chylomicrons.

Original language	English
Pages (from-to)	795-797
Number of pages	3
Journal	Biochemical Pharmacology
Volume	27
Issue number	5
DOIs	https://doi.org/10.1016/0378-4274(77)90031-5
Publication status	Published - 1978

ASJC Scopus subject areas

Pharmacology

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title = "Effect of a contraceptive steroid combination on the 'serum activation' of lipoprotein lipase in rats",

abstract = "Our investigation on serum obtained from control rats and from rats treated with a steroid contraceptive drug (SCD) showed that serum from SCD treated rats had a lower activating capacity for lipoprotein lipase from rat epididymal adipose tissue. A similar result was observed when HDL apolipoproteins obtained from serum of these 2 groups of rats were tested against a lipoprotein lipase preparation. The data suggest a deficiency or an alteration of some serum cofactors (probably apolipoproteins of the C group). The observation that chylomicrons from SCD treated rats were slightly poorer substrate for lipoprotein lipase than those from control rats supports the hypothesis of a cofactor deficiency rather than a transfer of apolipoproteins from HDL to chylomicrons.",

author = "A. Bizzi and Tacconi, {M. T.} and E. Veneroni and M. Cini and S. Garattini",

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T1 - Effect of a contraceptive steroid combination on the 'serum activation' of lipoprotein lipase in rats

AU - Bizzi, A.

AU - Tacconi, M. T.

AU - Veneroni, E.

AU - Cini, M.

AU - Garattini, S.

PY - 1978

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N2 - Our investigation on serum obtained from control rats and from rats treated with a steroid contraceptive drug (SCD) showed that serum from SCD treated rats had a lower activating capacity for lipoprotein lipase from rat epididymal adipose tissue. A similar result was observed when HDL apolipoproteins obtained from serum of these 2 groups of rats were tested against a lipoprotein lipase preparation. The data suggest a deficiency or an alteration of some serum cofactors (probably apolipoproteins of the C group). The observation that chylomicrons from SCD treated rats were slightly poorer substrate for lipoprotein lipase than those from control rats supports the hypothesis of a cofactor deficiency rather than a transfer of apolipoproteins from HDL to chylomicrons.

AB - Our investigation on serum obtained from control rats and from rats treated with a steroid contraceptive drug (SCD) showed that serum from SCD treated rats had a lower activating capacity for lipoprotein lipase from rat epididymal adipose tissue. A similar result was observed when HDL apolipoproteins obtained from serum of these 2 groups of rats were tested against a lipoprotein lipase preparation. The data suggest a deficiency or an alteration of some serum cofactors (probably apolipoproteins of the C group). The observation that chylomicrons from SCD treated rats were slightly poorer substrate for lipoprotein lipase than those from control rats supports the hypothesis of a cofactor deficiency rather than a transfer of apolipoproteins from HDL to chylomicrons.

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Effect of a contraceptive steroid combination on the 'serum activation' of lipoprotein lipase in rats

Abstract

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