Although the role of dopaminergic system in the regulation of LH secretion is not fully established, the weight of evidence supports an inhibitory role. Yen (1980) showed that dopamine infusion decreases plasma LH levels in women with PCO Syndrome. It is known that Nomifensine activates central dopaminergic neurotransmission via presynaptic events without directly affecting DA receptors sites. In 15 polycystic ovary syndrome cases, Nomifensine failed to decrease basal and GnRH stimulated LH levels, although PRL levels were lowered. Although the increased dopaminergic activity was showed by PRL decrease, central dopaminergic activation had no effect on LH secretion. The finding may be explained by the predominant effect of DA system on physiological control of PRL secretion compared with the effects on LH secretion. Moreover in PCO patients pituitary sensitivity to GnRH is increased and in this pathological condition activation of central DA system may not lower the LH level. These results showed that Nomifensine induced central dopamine activation but did not influence basal and stimulated LH levels in PCO Syndrome.
|Number of pages||3|
|Journal||Acta Europaea Fertilitatis|
|Publication status||Published - 1981|
ASJC Scopus subject areas
- Obstetrics and Gynaecology