Effect of a gluten-free diet on cortical excitability in adults with celiac disease

Rita Bella, Giuseppe Lanza, Mariagiovanna Cantone, Salvatore Giuffrida, Valentina Puglisi, Luisa Vinciguerra, Manuela Pennisi, Riccardo Ricceri, Carmela Cinzia D'Agate, Giulia Malaguarnera, Raffaele Ferri, Giovanni Pennisi

Research output: Contribution to journalArticle

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Abstract

Introduction: An imbalance between excitatory and inhibitory synaptic excitability was observed in de novo patients with celiac disease (CD) in a previous study with Transcranial Magnetic Stimulation (TMS), suggesting a subclinical involvement of GABAergic and glutamatergic neurotransmission in asymptomatic patients. The aim of this investigation was to monitor the eventual changes in the same cohort of patients, evaluated after a period of gluten-free diet. Methods: Patients were re-evaluated after a median period of 16 months during which an adequate gluten-free diet was maintained. Clinical, cognitive and neuropsychiatric assessment was repeated, as well as cortical excitability by means of single- and paired-pulse TMS from the first dorsal interosseous muscle of the dominant hand. Results: Compared to baseline, patients showed a significant decrease of the median resting motor threshold (from 35% to 33%, p

Original languageEnglish
Article numbere0129218
JournalPLoS One
Volume10
Issue number6
DOIs
Publication statusPublished - Jun 8 2015

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gluten-free diet
Gluten-Free Diet
celiac disease
Glutens
Celiac Disease
Nutrition
Transcranial Magnetic Stimulation
Muscle
Synaptic Transmission
hands
Hand
Cortical Excitability
Muscles
muscles
monitoring

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Bella, R., Lanza, G., Cantone, M., Giuffrida, S., Puglisi, V., Vinciguerra, L., ... Pennisi, G. (2015). Effect of a gluten-free diet on cortical excitability in adults with celiac disease. PLoS One, 10(6), [e0129218]. https://doi.org/10.1371/journal.pone.0129218

Effect of a gluten-free diet on cortical excitability in adults with celiac disease. / Bella, Rita; Lanza, Giuseppe; Cantone, Mariagiovanna; Giuffrida, Salvatore; Puglisi, Valentina; Vinciguerra, Luisa; Pennisi, Manuela; Ricceri, Riccardo; D'Agate, Carmela Cinzia; Malaguarnera, Giulia; Ferri, Raffaele; Pennisi, Giovanni.

In: PLoS One, Vol. 10, No. 6, e0129218, 08.06.2015.

Research output: Contribution to journalArticle

Bella, R, Lanza, G, Cantone, M, Giuffrida, S, Puglisi, V, Vinciguerra, L, Pennisi, M, Ricceri, R, D'Agate, CC, Malaguarnera, G, Ferri, R & Pennisi, G 2015, 'Effect of a gluten-free diet on cortical excitability in adults with celiac disease', PLoS One, vol. 10, no. 6, e0129218. https://doi.org/10.1371/journal.pone.0129218
Bella R, Lanza G, Cantone M, Giuffrida S, Puglisi V, Vinciguerra L et al. Effect of a gluten-free diet on cortical excitability in adults with celiac disease. PLoS One. 2015 Jun 8;10(6). e0129218. https://doi.org/10.1371/journal.pone.0129218
Bella, Rita ; Lanza, Giuseppe ; Cantone, Mariagiovanna ; Giuffrida, Salvatore ; Puglisi, Valentina ; Vinciguerra, Luisa ; Pennisi, Manuela ; Ricceri, Riccardo ; D'Agate, Carmela Cinzia ; Malaguarnera, Giulia ; Ferri, Raffaele ; Pennisi, Giovanni. / Effect of a gluten-free diet on cortical excitability in adults with celiac disease. In: PLoS One. 2015 ; Vol. 10, No. 6.
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