Effect of a gluten-free diet on the risk of enteropathy-associated T-cell lymphoma in celiac disease

Marco Silano; Umberto Volta; Alessandro De Vincenzi; Mariarita Dessì; Massimo De Vincenzi; G. Gasbarrini; V. De Vitis; L. Greco; S. Auricchio; D. Santini; F. Scaggiante M.; M. Vincenzi; [No Value] Federici; E. Castellano; A. Calvi; S. Grosso; J. Campanella; G. R. Corazza; G. Sandri; G. Giorgetti; U. Volta; C. Parisi; S. Lo Perfido; F. Perri; V. Festa; M. A. Pelli; M. L. Cavalletti; S. Segato; M. Curzio; M. Pennazio; F. P. Rossini; A. Picarelli; A. Pera; E. Ercole; M. T. Passaleva; M. Barbato; P. Usai; M. F. Dore; F. Chilovi; L. Piazzi; L. Zancanella; V. Boarino; A. Ferrari

doi:10.1007/s10620-007-9952-8

Effect of a gluten-free diet on the risk of enteropathy-associated T-cell lymphoma in celiac disease

Marco Silano, Umberto Volta, Alessandro De Vincenzi, Mariarita Dessì, Massimo De Vincenzi, G. Gasbarrini, V. De Vitis, L. Greco, S. Auricchio, D. Santini, F. Scaggiante M., M. Vincenzi, [No Value] Federici, E. Castellano, A. Calvi, S. Grosso, J. Campanella, G. R. Corazza, G. Sandri, G. GiorgettiU. Volta, C. Parisi, S. Lo Perfido, F. Perri, V. Festa, M. A. Pelli, M. L. Cavalletti, S. Segato, M. Curzio, M. Pennazio, F. P. Rossini, A. Picarelli, A. Pera, E. Ercole, M. T. Passaleva, M. Barbato, P. Usai, M. F. Dore, F. Chilovi, L. Piazzi, L. Zancanella, V. Boarino, A. Ferrari

Research output: Contribution to journal › Article › peer-review

Abstract

Patients with celiac disease have an increased rate of enteropathy- associated T-cell lymphoma, but conflicting data are available about the protective role of a gluten-free diet with regard to the development of this malignancy. We followed 1,757 celiac patients for a total period of 31,801 person-years, collecting data about the frequency of gluten intake and the incidence of the enteropathy-associated T-cell lymphoma. Out of the nine celiac patients who developed an intestinal lymphoma [standard morbidity ratio of 6.42 (95% CI = 2.9-12.2; P <0.001)], only two kept a strict gluten-free diet after the diagnosis of celiac diasese and developed the malignancy after the peridiagnosis period of 3 years, dropping therefore the standard morbidity ratio to 0.22 (95%CI = 0.02-0.88; P <0.001). The risk of developing an intestinal lymphoma for the celiac patients that used to have dietary gluten was significant (X² = 4.8 P = 0.01). These results show that a strict gluten-free diet is protective towards the development of enteropathy-associated T-cell lymphoma.

Original language	English
Pages (from-to)	972-976
Number of pages	5
Journal	Digestive Diseases and Sciences
Volume	53
Issue number	4
DOIs	https://doi.org/10.1007/s10620-007-9952-8
Publication status	Published - Apr 2008

Keywords

Celiac disease
Enteropathy-associated T-cell lymphoma
Gluten-free diet

ASJC Scopus subject areas

Gastroenterology

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10.1007/s10620-007-9952-8

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Silano, M., Volta, U., Vincenzi, A. D., Dessì, M., Vincenzi, M. D., Gasbarrini, G., De Vitis, V., Greco, L., Auricchio, S., Santini, D., Scaggiante M., F., Vincenzi, M., Federici, N. V., Castellano, E., Calvi, A., Grosso, S., Campanella, J., Corazza, G. R., Sandri, G., ... Ferrari, A. (2008). Effect of a gluten-free diet on the risk of enteropathy-associated T-cell lymphoma in celiac disease. Digestive Diseases and Sciences, 53(4), 972-976. https://doi.org/10.1007/s10620-007-9952-8

Effect of a gluten-free diet on the risk of enteropathy-associated T-cell lymphoma in celiac disease. / Silano, Marco; Volta, Umberto; Vincenzi, Alessandro De; Dessì, Mariarita; Vincenzi, Massimo De; Gasbarrini, G.; De Vitis, V.; Greco, L.; Auricchio, S.; Santini, D.; Scaggiante M., F.; Vincenzi, M.; Federici, [No Value]; Castellano, E.; Calvi, A.; Grosso, S.; Campanella, J.; Corazza, G. R.; Sandri, G.; Giorgetti, G.; Volta, U.; Parisi, C.; Lo Perfido, S.; Perri, F.; Festa, V.; Pelli, M. A.; Cavalletti, M. L.; Segato, S.; Curzio, M.; Pennazio, M.; Rossini, F. P.; Picarelli, A.; Pera, A.; Ercole, E.; Passaleva, M. T.; Barbato, M.; Usai, P.; Dore, M. F.; Chilovi, F.; Piazzi, L.; Zancanella, L.; Boarino, V.; Ferrari, A.

In: Digestive Diseases and Sciences, Vol. 53, No. 4, 04.2008, p. 972-976.

Research output: Contribution to journal › Article › peer-review

Silano, M, Volta, U, Vincenzi, AD, Dessì, M, Vincenzi, MD, Gasbarrini, G, De Vitis, V, Greco, L, Auricchio, S, Santini, D, Scaggiante M., F, Vincenzi, M, Federici, NV, Castellano, E, Calvi, A, Grosso, S, Campanella, J, Corazza, GR, Sandri, G, Giorgetti, G, Volta, U, Parisi, C, Lo Perfido, S, Perri, F, Festa, V, Pelli, MA, Cavalletti, ML, Segato, S, Curzio, M, Pennazio, M, Rossini, FP, Picarelli, A, Pera, A, Ercole, E, Passaleva, MT, Barbato, M, Usai, P, Dore, MF, Chilovi, F, Piazzi, L, Zancanella, L, Boarino, V & Ferrari, A 2008, 'Effect of a gluten-free diet on the risk of enteropathy-associated T-cell lymphoma in celiac disease', Digestive Diseases and Sciences, vol. 53, no. 4, pp. 972-976. https://doi.org/10.1007/s10620-007-9952-8

Silano, Marco ; Volta, Umberto ; Vincenzi, Alessandro De ; Dessì, Mariarita ; Vincenzi, Massimo De ; Gasbarrini, G. ; De Vitis, V. ; Greco, L. ; Auricchio, S. ; Santini, D. ; Scaggiante M., F. ; Vincenzi, M. ; Federici, [No Value] ; Castellano, E. ; Calvi, A. ; Grosso, S. ; Campanella, J. ; Corazza, G. R. ; Sandri, G. ; Giorgetti, G. ; Volta, U. ; Parisi, C. ; Lo Perfido, S. ; Perri, F. ; Festa, V. ; Pelli, M. A. ; Cavalletti, M. L. ; Segato, S. ; Curzio, M. ; Pennazio, M. ; Rossini, F. P. ; Picarelli, A. ; Pera, A. ; Ercole, E. ; Passaleva, M. T. ; Barbato, M. ; Usai, P. ; Dore, M. F. ; Chilovi, F. ; Piazzi, L. ; Zancanella, L. ; Boarino, V. ; Ferrari, A. / Effect of a gluten-free diet on the risk of enteropathy-associated T-cell lymphoma in celiac disease. In: Digestive Diseases and Sciences. 2008 ; Vol. 53, No. 4. pp. 972-976.

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title = "Effect of a gluten-free diet on the risk of enteropathy-associated T-cell lymphoma in celiac disease",

abstract = "Patients with celiac disease have an increased rate of enteropathy- associated T-cell lymphoma, but conflicting data are available about the protective role of a gluten-free diet with regard to the development of this malignancy. We followed 1,757 celiac patients for a total period of 31,801 person-years, collecting data about the frequency of gluten intake and the incidence of the enteropathy-associated T-cell lymphoma. Out of the nine celiac patients who developed an intestinal lymphoma [standard morbidity ratio of 6.42 (95% CI = 2.9-12.2; P <0.001)], only two kept a strict gluten-free diet after the diagnosis of celiac diasese and developed the malignancy after the peridiagnosis period of 3 years, dropping therefore the standard morbidity ratio to 0.22 (95%CI = 0.02-0.88; P <0.001). The risk of developing an intestinal lymphoma for the celiac patients that used to have dietary gluten was significant (X2 = 4.8 P = 0.01). These results show that a strict gluten-free diet is protective towards the development of enteropathy-associated T-cell lymphoma.",

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author = "Marco Silano and Umberto Volta and Vincenzi, {Alessandro De} and Mariarita Dess{\`i} and Vincenzi, {Massimo De} and G. Gasbarrini and {De Vitis}, V. and L. Greco and S. Auricchio and D. Santini and {Scaggiante M.}, F. and M. Vincenzi and Federici, {[No Value]} and E. Castellano and A. Calvi and S. Grosso and J. Campanella and Corazza, {G. R.} and G. Sandri and G. Giorgetti and U. Volta and C. Parisi and {Lo Perfido}, S. and F. Perri and V. Festa and Pelli, {M. A.} and Cavalletti, {M. L.} and S. Segato and M. Curzio and M. Pennazio and Rossini, {F. P.} and A. Picarelli and A. Pera and E. Ercole and Passaleva, {M. T.} and M. Barbato and P. Usai and Dore, {M. F.} and F. Chilovi and L. Piazzi and L. Zancanella and V. Boarino and A. Ferrari",

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AU - Silano, Marco

AU - Volta, Umberto

AU - Vincenzi, Alessandro De

AU - Dessì, Mariarita

AU - Vincenzi, Massimo De

AU - Gasbarrini, G.

AU - De Vitis, V.

AU - Greco, L.

AU - Auricchio, S.

AU - Santini, D.

AU - Scaggiante M., F.

AU - Vincenzi, M.

AU - Federici, [No Value]

AU - Castellano, E.

AU - Calvi, A.

AU - Grosso, S.

AU - Campanella, J.

AU - Corazza, G. R.

AU - Sandri, G.

AU - Giorgetti, G.

AU - Volta, U.

AU - Parisi, C.

AU - Lo Perfido, S.

AU - Perri, F.

AU - Festa, V.

AU - Pelli, M. A.

AU - Cavalletti, M. L.

AU - Segato, S.

AU - Curzio, M.

AU - Pennazio, M.

AU - Rossini, F. P.

AU - Picarelli, A.

AU - Pera, A.

AU - Ercole, E.

AU - Passaleva, M. T.

AU - Barbato, M.

AU - Usai, P.

AU - Dore, M. F.

AU - Chilovi, F.

AU - Piazzi, L.

AU - Zancanella, L.

AU - Boarino, V.

AU - Ferrari, A.

PY - 2008/4

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N2 - Patients with celiac disease have an increased rate of enteropathy- associated T-cell lymphoma, but conflicting data are available about the protective role of a gluten-free diet with regard to the development of this malignancy. We followed 1,757 celiac patients for a total period of 31,801 person-years, collecting data about the frequency of gluten intake and the incidence of the enteropathy-associated T-cell lymphoma. Out of the nine celiac patients who developed an intestinal lymphoma [standard morbidity ratio of 6.42 (95% CI = 2.9-12.2; P <0.001)], only two kept a strict gluten-free diet after the diagnosis of celiac diasese and developed the malignancy after the peridiagnosis period of 3 years, dropping therefore the standard morbidity ratio to 0.22 (95%CI = 0.02-0.88; P <0.001). The risk of developing an intestinal lymphoma for the celiac patients that used to have dietary gluten was significant (X2 = 4.8 P = 0.01). These results show that a strict gluten-free diet is protective towards the development of enteropathy-associated T-cell lymphoma.

AB - Patients with celiac disease have an increased rate of enteropathy- associated T-cell lymphoma, but conflicting data are available about the protective role of a gluten-free diet with regard to the development of this malignancy. We followed 1,757 celiac patients for a total period of 31,801 person-years, collecting data about the frequency of gluten intake and the incidence of the enteropathy-associated T-cell lymphoma. Out of the nine celiac patients who developed an intestinal lymphoma [standard morbidity ratio of 6.42 (95% CI = 2.9-12.2; P <0.001)], only two kept a strict gluten-free diet after the diagnosis of celiac diasese and developed the malignancy after the peridiagnosis period of 3 years, dropping therefore the standard morbidity ratio to 0.22 (95%CI = 0.02-0.88; P <0.001). The risk of developing an intestinal lymphoma for the celiac patients that used to have dietary gluten was significant (X2 = 4.8 P = 0.01). These results show that a strict gluten-free diet is protective towards the development of enteropathy-associated T-cell lymphoma.

KW - Celiac disease

KW - Enteropathy-associated T-cell lymphoma

KW - Gluten-free diet

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ER -

Effect of a gluten-free diet on the risk of enteropathy-associated T-cell lymphoma in celiac disease

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