Effect of a gluten-free diet on the risk of enteropathy-associated T-cell lymphoma in celiac disease

Marco Silano, Umberto Volta, Alessandro De Vincenzi, Mariarita Dessì, Massimo De Vincenzi, G. Gasbarrini, V. De Vitis, L. Greco, S. Auricchio, D. Santini, F. Scaggiante M., M. Vincenzi, [No Value] Federici, E. Castellano, A. Calvi, S. Grosso, J. Campanella, G. R. Corazza, G. Sandri, G. GiorgettiU. Volta, C. Parisi, S. Lo Perfido, F. Perri, V. Festa, M. A. Pelli, M. L. Cavalletti, S. Segato, M. Curzio, M. Pennazio, F. P. Rossini, A. Picarelli, A. Pera, E. Ercole, M. T. Passaleva, M. Barbato, P. Usai, M. F. Dore, F. Chilovi, L. Piazzi, L. Zancanella, V. Boarino, A. Ferrari

Research output: Contribution to journalArticlepeer-review


Patients with celiac disease have an increased rate of enteropathy- associated T-cell lymphoma, but conflicting data are available about the protective role of a gluten-free diet with regard to the development of this malignancy. We followed 1,757 celiac patients for a total period of 31,801 person-years, collecting data about the frequency of gluten intake and the incidence of the enteropathy-associated T-cell lymphoma. Out of the nine celiac patients who developed an intestinal lymphoma [standard morbidity ratio of 6.42 (95% CI = 2.9-12.2; P <0.001)], only two kept a strict gluten-free diet after the diagnosis of celiac diasese and developed the malignancy after the peridiagnosis period of 3 years, dropping therefore the standard morbidity ratio to 0.22 (95%CI = 0.02-0.88; P <0.001). The risk of developing an intestinal lymphoma for the celiac patients that used to have dietary gluten was significant (X2 = 4.8 P = 0.01). These results show that a strict gluten-free diet is protective towards the development of enteropathy-associated T-cell lymphoma.

Original languageEnglish
Pages (from-to)972-976
Number of pages5
JournalDigestive Diseases and Sciences
Issue number4
Publication statusPublished - Apr 2008


  • Celiac disease
  • Enteropathy-associated T-cell lymphoma
  • Gluten-free diet

ASJC Scopus subject areas

  • Gastroenterology


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