TY - JOUR
T1 - Effect of a Low Glycemic Index Mediterranean Diet on non-alcoholic fatty liver disease. A randomized controlled clinici trial
AU - Misciagna, G.
AU - Del Pilar Díaz, M.
AU - Caramia, D. V.
AU - Bonfiglio, C.
AU - Franco, I.
AU - Noviello, M. R.
AU - Chiloiro, M.
AU - Abbrescia, D. I.
AU - Mirizzi, A.
AU - Tanzi, M.
AU - Caruso, M. G.
AU - Correale, M.
AU - Reddavide, R.
AU - Inguaggiato, R.
AU - Cisternino, A. M.
AU - Osella, Alberto Rubén
PY - 2016/9/29
Y1 - 2016/9/29
N2 - Introduction: Non-Alcoholic Fatty Liver Disease (NAFLD) is currently the most common form of liver disease worldwide affecting all ages and ethnic groups and it has become a consistent threat even in young people. Our aim was to estimate the effect of a Low Glycemic Index Mediterranean Diet (LGIMD) on the NAFLD score as measured by a Liver Ultrasonography (LUS). Design: NUTRIzione in EPAtologia (NUTRIEPA) is a population-based Double-Blind RCT. Data were collected in 2011 and analyzed in 2013-14. Setting/participants: 98 men and women coming from Putignano (Puglia, Southern Italy) were drawn from a previous randomly sampled population-based study and identified as having moderate or severe NAFLD. Intervention: The intervention strategy was the assignment of a LGIMD or a control diet. Outcome measures: The main outcome measure was NAFLD score, defined by LUS. Results: After randomization, 50 subjects were assigned to a LGIMD and 48 to a control diet. The study lasted six months and all participants were subject to monthly controls/checks. Adherence to the LGIMD as measured by Mediterranean Adequacy Index (MAI) showed a median of 10.1. A negative interaction between time and LGIMD on the NAFLD score (−4.14, 95% CI −6.78,−1.49) was observed, and became more evident at the sixth month (−4.43, 95%CI −7.15, −1.71). A positive effect of the interaction among LGIMD, time and age (Third month: 0.07, 95% CI 0.02, 0.12; Sixth month: 0.08, 95% CI 0.03,0.13) was also observed. Conclusions: LGIMD was found to decrease the NAFLD score in a relatively short time. Encouraging those subjects who do not seek medical attention but still have NAFLD to follow a LGIMD and other life-style interventions, may reduce the degree of severity of the disease. Dietary intervention of this kind, could also form the cornerstone of primary prevention of Type 2 Diabetes Mellitus (T2DM) and cardiovascular disease.
AB - Introduction: Non-Alcoholic Fatty Liver Disease (NAFLD) is currently the most common form of liver disease worldwide affecting all ages and ethnic groups and it has become a consistent threat even in young people. Our aim was to estimate the effect of a Low Glycemic Index Mediterranean Diet (LGIMD) on the NAFLD score as measured by a Liver Ultrasonography (LUS). Design: NUTRIzione in EPAtologia (NUTRIEPA) is a population-based Double-Blind RCT. Data were collected in 2011 and analyzed in 2013-14. Setting/participants: 98 men and women coming from Putignano (Puglia, Southern Italy) were drawn from a previous randomly sampled population-based study and identified as having moderate or severe NAFLD. Intervention: The intervention strategy was the assignment of a LGIMD or a control diet. Outcome measures: The main outcome measure was NAFLD score, defined by LUS. Results: After randomization, 50 subjects were assigned to a LGIMD and 48 to a control diet. The study lasted six months and all participants were subject to monthly controls/checks. Adherence to the LGIMD as measured by Mediterranean Adequacy Index (MAI) showed a median of 10.1. A negative interaction between time and LGIMD on the NAFLD score (−4.14, 95% CI −6.78,−1.49) was observed, and became more evident at the sixth month (−4.43, 95%CI −7.15, −1.71). A positive effect of the interaction among LGIMD, time and age (Third month: 0.07, 95% CI 0.02, 0.12; Sixth month: 0.08, 95% CI 0.03,0.13) was also observed. Conclusions: LGIMD was found to decrease the NAFLD score in a relatively short time. Encouraging those subjects who do not seek medical attention but still have NAFLD to follow a LGIMD and other life-style interventions, may reduce the degree of severity of the disease. Dietary intervention of this kind, could also form the cornerstone of primary prevention of Type 2 Diabetes Mellitus (T2DM) and cardiovascular disease.
KW - Hepatic steatosis
KW - low glycemic index Mediterranean diet
KW - Mediterranean diet
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U2 - 10.1007/s12603-016-0809-8
DO - 10.1007/s12603-016-0809-8
M3 - Article
AN - SCOPUS:84989205082
SP - 1
EP - 9
JO - Journal of Nutrition, Health and Aging
JF - Journal of Nutrition, Health and Aging
SN - 1279-7707
ER -