Abstract
Objectives: Aging might affect the effectiveness of the sole supplementation of calcium and vitamin D in postmenopausal women, due to the development of vitamin D resistance in the gut, which limits calcium absorption. Thus, we wanted to test the efficacy of a mixture of calcium (500 mg), 25-hydroxyvitamin D [25(OH)D; 300 IU], inulin (3 g) and soy isoflavones (40 mg), to improve calcium absorption in this type of population. Study design It is a retrospective study on otherwise healthy post-menopausal women. Main outcome measures: The following parameters were evaluated at baseline and after 3 months of supplementation: daily calciuria as an indirect marker of calcium absorption, serum 25(OH)D, parathormone, insulin-like growth factor 1 (IGF1) as a marker of bone anabolism, collagen telopeptide and osteocalcin as markers of bone resorption and bone turnover, respectively. Results: Twenty-eight women (median age 67 years) were included in the analysis. The supplementation markedly increased daily calciuria (+60 %; p = 0.00009), while reducing parathormone levels (-18 %; p = 0.02) and leaving 25(OH)D unaltered. An increase in IGF1 (+16 %; p = 0.01) and a reduction in collagen telopeptide (-17 %; p = 0.04) were observed, too, as well as a modest trend towards osteocalcin reduction, although not significant. Conclusions: These results suggest that the considered mixture improved intestinal calcium absorption and bone metabolism in post-menopausal women. Since the amount of supplemented calcium was relatively low and 25(OH)D levels were unchanged, the observed effects are likely due to the combined contributions of inulin and soy isoflavones.
| Original language | English |
|---|---|
| Pages (from-to) | 611-617 |
| Number of pages | 7 |
| Journal | Aging clinical and experimental research |
| Volume | 25 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Dec 2013 |
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Keywords
- 25-hydroxyvitamin D
- Calcium supplementation
- Inulin
- Post-menopause
- Soy isoflavones
ASJC Scopus subject areas
- Ageing
- Geriatrics and Gerontology
Cite this
Effect of a mixture of calcium, vitamin D, inulin and soy isoflavones on bone metabolism in post-menopausal women : A retrospective analysis. / Bevilacqua, Maurizio; Righini, Velella; Certan, Diana; Gandolini, Giorgio; Alemanni, Matteo.
In: Aging clinical and experimental research, Vol. 25, No. 6, 12.2013, p. 611-617.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of a mixture of calcium, vitamin D, inulin and soy isoflavones on bone metabolism in post-menopausal women
T2 - A retrospective analysis
AU - Bevilacqua, Maurizio
AU - Righini, Velella
AU - Certan, Diana
AU - Gandolini, Giorgio
AU - Alemanni, Matteo
PY - 2013/12
Y1 - 2013/12
N2 - Objectives: Aging might affect the effectiveness of the sole supplementation of calcium and vitamin D in postmenopausal women, due to the development of vitamin D resistance in the gut, which limits calcium absorption. Thus, we wanted to test the efficacy of a mixture of calcium (500 mg), 25-hydroxyvitamin D [25(OH)D; 300 IU], inulin (3 g) and soy isoflavones (40 mg), to improve calcium absorption in this type of population. Study design It is a retrospective study on otherwise healthy post-menopausal women. Main outcome measures: The following parameters were evaluated at baseline and after 3 months of supplementation: daily calciuria as an indirect marker of calcium absorption, serum 25(OH)D, parathormone, insulin-like growth factor 1 (IGF1) as a marker of bone anabolism, collagen telopeptide and osteocalcin as markers of bone resorption and bone turnover, respectively. Results: Twenty-eight women (median age 67 years) were included in the analysis. The supplementation markedly increased daily calciuria (+60 %; p = 0.00009), while reducing parathormone levels (-18 %; p = 0.02) and leaving 25(OH)D unaltered. An increase in IGF1 (+16 %; p = 0.01) and a reduction in collagen telopeptide (-17 %; p = 0.04) were observed, too, as well as a modest trend towards osteocalcin reduction, although not significant. Conclusions: These results suggest that the considered mixture improved intestinal calcium absorption and bone metabolism in post-menopausal women. Since the amount of supplemented calcium was relatively low and 25(OH)D levels were unchanged, the observed effects are likely due to the combined contributions of inulin and soy isoflavones.
AB - Objectives: Aging might affect the effectiveness of the sole supplementation of calcium and vitamin D in postmenopausal women, due to the development of vitamin D resistance in the gut, which limits calcium absorption. Thus, we wanted to test the efficacy of a mixture of calcium (500 mg), 25-hydroxyvitamin D [25(OH)D; 300 IU], inulin (3 g) and soy isoflavones (40 mg), to improve calcium absorption in this type of population. Study design It is a retrospective study on otherwise healthy post-menopausal women. Main outcome measures: The following parameters were evaluated at baseline and after 3 months of supplementation: daily calciuria as an indirect marker of calcium absorption, serum 25(OH)D, parathormone, insulin-like growth factor 1 (IGF1) as a marker of bone anabolism, collagen telopeptide and osteocalcin as markers of bone resorption and bone turnover, respectively. Results: Twenty-eight women (median age 67 years) were included in the analysis. The supplementation markedly increased daily calciuria (+60 %; p = 0.00009), while reducing parathormone levels (-18 %; p = 0.02) and leaving 25(OH)D unaltered. An increase in IGF1 (+16 %; p = 0.01) and a reduction in collagen telopeptide (-17 %; p = 0.04) were observed, too, as well as a modest trend towards osteocalcin reduction, although not significant. Conclusions: These results suggest that the considered mixture improved intestinal calcium absorption and bone metabolism in post-menopausal women. Since the amount of supplemented calcium was relatively low and 25(OH)D levels were unchanged, the observed effects are likely due to the combined contributions of inulin and soy isoflavones.
KW - 25-hydroxyvitamin D
KW - Calcium supplementation
KW - Inulin
KW - Post-menopause
KW - Soy isoflavones
UR - http://www.scopus.com/inward/record.url?scp=84892871868&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84892871868&partnerID=8YFLogxK
U2 - 10.1007/s40520-013-0093-y
DO - 10.1007/s40520-013-0093-y
M3 - Article
C2 - 23907774
AN - SCOPUS:84892871868
VL - 25
SP - 611
EP - 617
JO - Aging clinical and experimental research
JF - Aging clinical and experimental research
SN - 1594-0667
IS - 6
ER -