Effect of a monoclonal antibody against GPs IIb-IIIa on platelet aggregation and ATP secretion

C. L. Balduini, F. Sinigallia, G. Damiani, G. Bertolino, A. Bisio, E. Zocchi

Research output: Contribution to journalArticlepeer-review

Abstract

A murine monoclonal antibody against glycoproteins IIb-IIIa of platelet membrane completely abolished platelet aggregation induced by epinephrine, arachidonic acid, and low concentration of collagen and thrombin, but it had only minor inhibitory effects on aggregation induced by ADP, higher amounts of collagen and thrombin, and these agents combined in pairs. The simultaneous studies of aggregation and ATP secretion demonstrated that aggregation plays an essential role in stimulating the platelet-release reaction, except for the thrombin-induced ATP secretion that seems to be largely dependent on fibrinogen binding to platelet surface.

Original languageEnglish
Pages (from-to)338-342
Number of pages5
JournalExperimental Hematology
Volume14
Issue number5
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Genetics
  • Hematology
  • Oncology
  • Transplantation

Fingerprint Dive into the research topics of 'Effect of a monoclonal antibody against GPs IIb-IIIa on platelet aggregation and ATP secretion'. Together they form a unique fingerprint.

Cite this