Effect of a monoclonal antibody against GPs IIb-IIIa on platelet aggregation and ATP secretion

C. L. Balduini; F. Sinigallia; G. Damiani; G. Bertolino; A. Bisio; E. Zocchi

Effect of a monoclonal antibody against GPs IIb-IIIa on platelet aggregation and ATP secretion

C. L. Balduini, F. Sinigallia, G. Damiani, G. Bertolino, A. Bisio, E. Zocchi

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

A murine monoclonal antibody against glycoproteins IIb-IIIa of platelet membrane completely abolished platelet aggregation induced by epinephrine, arachidonic acid, and low concentration of collagen and thrombin, but it had only minor inhibitory effects on aggregation induced by ADP, higher amounts of collagen and thrombin, and these agents combined in pairs. The simultaneous studies of aggregation and ATP secretion demonstrated that aggregation plays an essential role in stimulating the platelet-release reaction, except for the thrombin-induced ATP secretion that seems to be largely dependent on fibrinogen binding to platelet surface.

Original language	English
Pages (from-to)	338-342
Number of pages	5
Journal	Experimental Hematology
Volume	14
Issue number	5
Publication status	Published - 1986

ASJC Scopus subject areas

Cancer Research
Cell Biology
Genetics
Hematology
Oncology
Transplantation

Access to Document

Fingerprint Dive into the research topics of 'Effect of a monoclonal antibody against GPs IIb-IIIa on platelet aggregation and ATP secretion'. Together they form a unique fingerprint.

Cite this

@article{6943d936e237424e924d0b13f67638e6,

title = "Effect of a monoclonal antibody against GPs IIb-IIIa on platelet aggregation and ATP secretion",

abstract = "A murine monoclonal antibody against glycoproteins IIb-IIIa of platelet membrane completely abolished platelet aggregation induced by epinephrine, arachidonic acid, and low concentration of collagen and thrombin, but it had only minor inhibitory effects on aggregation induced by ADP, higher amounts of collagen and thrombin, and these agents combined in pairs. The simultaneous studies of aggregation and ATP secretion demonstrated that aggregation plays an essential role in stimulating the platelet-release reaction, except for the thrombin-induced ATP secretion that seems to be largely dependent on fibrinogen binding to platelet surface.",

author = "Balduini, {C. L.} and F. Sinigallia and G. Damiani and G. Bertolino and A. Bisio and E. Zocchi",

year = "1986",

language = "English",

volume = "14",

pages = "338--342",

journal = "Experimental Hematology",

issn = "0301-472X",

publisher = "Elsevier Inc.",

number = "5",

}

TY - JOUR

T1 - Effect of a monoclonal antibody against GPs IIb-IIIa on platelet aggregation and ATP secretion

AU - Balduini, C. L.

AU - Sinigallia, F.

AU - Damiani, G.

AU - Bertolino, G.

AU - Bisio, A.

AU - Zocchi, E.

PY - 1986

Y1 - 1986

N2 - A murine monoclonal antibody against glycoproteins IIb-IIIa of platelet membrane completely abolished platelet aggregation induced by epinephrine, arachidonic acid, and low concentration of collagen and thrombin, but it had only minor inhibitory effects on aggregation induced by ADP, higher amounts of collagen and thrombin, and these agents combined in pairs. The simultaneous studies of aggregation and ATP secretion demonstrated that aggregation plays an essential role in stimulating the platelet-release reaction, except for the thrombin-induced ATP secretion that seems to be largely dependent on fibrinogen binding to platelet surface.

AB - A murine monoclonal antibody against glycoproteins IIb-IIIa of platelet membrane completely abolished platelet aggregation induced by epinephrine, arachidonic acid, and low concentration of collagen and thrombin, but it had only minor inhibitory effects on aggregation induced by ADP, higher amounts of collagen and thrombin, and these agents combined in pairs. The simultaneous studies of aggregation and ATP secretion demonstrated that aggregation plays an essential role in stimulating the platelet-release reaction, except for the thrombin-induced ATP secretion that seems to be largely dependent on fibrinogen binding to platelet surface.

UR - http://www.scopus.com/inward/record.url?scp=0022510723&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022510723&partnerID=8YFLogxK

M3 - Article

C2 - 3011483

AN - SCOPUS:0022510723

VL - 14

SP - 338

EP - 342

JO - Experimental Hematology

JF - Experimental Hematology

SN - 0301-472X

IS - 5

ER -