Effect of a single high-fat meal on endothelial function in patients with the metabolic syndrome: Role of tumor necrosis factor-α

Katherine Esposito, Miryam Ciotola, Ferdinando C. Sasso, Domenico Cozzolino, Franco Saccomanno, Roberta Assaloni, Antonio Ceriello, Dario Giugliano

Research output: Contribution to journalArticle

Abstract

Background and aims: A single high-fat meal may induce endothelial activation and dysfunction in both normal subjects and in patients with type 2 diabetes. The aim of this study was to assess the effect of a high-fat meal on endothelial function in patients with the metabolic syndrome. Methods and results: Twenty-five patients with the metabolic syndrome (ATP III criteria) were matched for sex, age and body mass index with 25 subjects without the metabolic syndrome. All subjects ate under supervision a high fat meal (760 calories) with 59% energy from fat, 12% energy from protein and 29% energy from carbohydrates. Compared with the control group, subjects with the metabolic syndrome had reduced endothelial function, as assessed with the l-arginine test, and higher circulating levels of TNF-α. Following the high-fat meal, both triglyceride and TNF-α levels increased more in subjects with the metabolic syndrome than in subjects without, while endothelial function decreased more in subjects with the metabolic syndrome. There was a significant relation between increases in TNF-α levels and decreases in endothelial function score in subjects with the metabolic syndrome (r = -0.39, P = 0.03). Conclusion: TNF-α levels are increased in subjects with the metabolic syndrome; moreover, a high-fat meal produces further increase in its levels associated with endothelial dysfunction.

Original languageEnglish
Pages (from-to)274-279
Number of pages6
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume17
Issue number4
DOIs
Publication statusPublished - May 2007

Fingerprint

Meals
Tumor Necrosis Factor-alpha
Fats
Type 2 Diabetes Mellitus
Arginine
Triglycerides
Body Mass Index
Adenosine Triphosphate
Carbohydrates
Control Groups
Proteins

Keywords

  • Endothelial function
  • High-fat meal
  • Metabolic syndrome
  • TNF-α
  • Triglycerides

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Cardiology and Cardiovascular Medicine
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Effect of a single high-fat meal on endothelial function in patients with the metabolic syndrome : Role of tumor necrosis factor-α. / Esposito, Katherine; Ciotola, Miryam; Sasso, Ferdinando C.; Cozzolino, Domenico; Saccomanno, Franco; Assaloni, Roberta; Ceriello, Antonio; Giugliano, Dario.

In: Nutrition, Metabolism and Cardiovascular Diseases, Vol. 17, No. 4, 05.2007, p. 274-279.

Research output: Contribution to journalArticle

Esposito, Katherine ; Ciotola, Miryam ; Sasso, Ferdinando C. ; Cozzolino, Domenico ; Saccomanno, Franco ; Assaloni, Roberta ; Ceriello, Antonio ; Giugliano, Dario. / Effect of a single high-fat meal on endothelial function in patients with the metabolic syndrome : Role of tumor necrosis factor-α. In: Nutrition, Metabolism and Cardiovascular Diseases. 2007 ; Vol. 17, No. 4. pp. 274-279.
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