Effect of a single oral dose of 600,000 IU of cholecalciferol on muscle strength: A study in young women

C. Cipriani, E. Romagnoli, V. Carnevale, R. Clerico, J. Pepe, M. Cilli, D. Diacinti, C. Savoriti, L. Colangelo, S. Minisola

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The effect of a single large oral dose of vitamin D on muscle function in young people with vitamin D deficiency has not been investigated so far. Aim: We evaluated the effect of a single oral dose of 600,000 IU of cholecalciferol on muscle strength. Subjects and methods: Eighteen young women with vitamin D deficiency received a single oral dose of 600,000 IU of cholecalciferol. We evaluated changes in maximal voluntary contraction (MVC) and speed of contraction (S) in response to cholecalciferol by using an hand held dynamometer at 3, 15, 30, 60 and 90 days, compared to baseline. Results: We observed no significant change in MVC and S values, a significant increase of 25-hydroxyvitamin D [25(OH)D] and 1,25-dihydroxyvitamin D [1,25(OH) 2D] and a significant decrease in serum parathyroid hormone (PTH) (p

Original languageEnglish
Pages (from-to)1051-1054
Number of pages4
JournalJournal of Endocrinological Investigation
Volume36
Issue number11
DOIs
Publication statusPublished - Dec 2013

Keywords

  • Cholecalciferol
  • Muscle
  • Strength
  • Vitamin D

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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