Effect of a somatostatin infusion on circulating levels of adipokines in obese women

Antonello E. Rigamonti, Alessandro Sartorio, Sara M. Bonomo, Marialuisa Giunta, Guido Grassi, Mario Perotti, Silvano G. Cella, Eugenio E. Müller, Angela I. Pincelli

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Abstract

Objective: Changes in circulating levels of many adipocyte-derived peptides, including adipokines such as adiponectin, leptin and tumor necrosis factor alpha (TNF-α), have been reported in obesity (OB). Somatostatin (SRIF) inhibits circulating levels of adiponectin and leptin in lean (LN) subjects, but the effect of a SRIF infusion on these adipokines, including TNF-α, in OB is to date unknown. Methods: Ten young women (5 OB and 5 LN) were studied. All subjects underwent an infusion of SRIF (9 μg/kg/h i.v., over 60 min), with blood samples drawn prior to and at different time intervals after SRIF administration. Plasma levels of adiponectin, leptin and TNF-α were measured at each interval. Results: Basal levels of leptin and TNF-α were significantly higher in OB than LN women, whereas levels of adiponectin were significantly lower in OB than LN subjects. SRIF significantly inhibited plasma concentrations of adiponectin (at 60 min) in both OB and LN women, without affecting those of leptin and TNF-α in either group. In LN subjects, the inhibitory effect of SRIF on plasma adiponectin persisted up to 150 min, whereas SRIF infusion withdrawal in OB women resulted in a prompt restoration of basal levels of the adipokine. Conclusions: Plasma concentrations of leptin and TNF-α, which are higher in OB than LN subjects, are unaffected by a SRIF infusion, which, in contrast, inhibits circulating levels of adiponectin in both groups, with a delayed return to the baseline secretion of the adipokine in LN subjects.

Original languageEnglish
Pages (from-to)1797-1802
Number of pages6
JournalMetabolism
Volume61
Issue number12
DOIs
Publication statusPublished - Dec 2012

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Keywords

  • Adiponectin, leptin
  • Obesity
  • Somatostatin
  • TNF-α

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Rigamonti, A. E., Sartorio, A., Bonomo, S. M., Giunta, M., Grassi, G., Perotti, M., Cella, S. G., Müller, E. E., & Pincelli, A. I. (2012). Effect of a somatostatin infusion on circulating levels of adipokines in obese women. Metabolism, 61(12), 1797-1802. https://doi.org/10.1016/j.metabol.2012.05.019