Effect of acetyl-L-carnitine in the treatment of painful peripheral neuropathies in HIV+ patients

Elio Scarpini, Giorgio Sacilotto, Pierluigi Baron, Marco Cusini, Guglielmo Scarlato

Research output: Contribution to journalArticle

Abstract

We studied the effects of acetyl-L-carnitine on pain in 16 HIV+ patients affected by painful distal symmetrical neuropathy. Patients were treated with 0.5-1 gr per day of acetyl-L-carnitine either i.m. or i.v. for 3 weeks. Pain intensity was measured before and after the treatment by the Huskisson's analogic scale. Ten patients (62.5%) reported an improvement of symptoms, five patients (31.25%) were unchanged, one patient worsened. The results of this open study show that acetyl-L-carnitine can have a role in the treatment of pain in distal symmetrical polyneuropathy related to HIV infection. However, further double-blind, placebo-controlled studies are needed to confirm these preliminary results.

Original languageEnglish
Pages (from-to)250-252
Number of pages3
JournalJournal of the Peripheral Nervous System
Volume2
Issue number3
Publication statusPublished - 1997

Fingerprint

Acetylcarnitine
Peripheral Nervous System Diseases
HIV
Pain
Therapeutics
Polyneuropathies
HIV Infections
Placebos
Painful Neuropathy

Keywords

  • Acetyl-L-carnitine
  • AIDS
  • Chronic pain
  • HIV+ neuropathy
  • Painful distal symmetrical polyneuropathy
  • Peripheral neuropathy
  • Therapy of peripheral neuropathies

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Effect of acetyl-L-carnitine in the treatment of painful peripheral neuropathies in HIV+ patients. / Scarpini, Elio; Sacilotto, Giorgio; Baron, Pierluigi; Cusini, Marco; Scarlato, Guglielmo.

In: Journal of the Peripheral Nervous System, Vol. 2, No. 3, 1997, p. 250-252.

Research output: Contribution to journalArticle

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