Effect of ACTH4-10 on nerve fiber regeneration after sciatic nerve crush in rabbits: An electrophysiological and morphological study

P. Girlanda, U. Muglia, G. Vita, R. Dattola, M. Santoro, A. Toscano, C. Venuto, M. L. Roberto, A. Baradello, M. Romano, C. Messina

Research output: Contribution to journalArticlepeer-review

Abstract

Crush of sciatic nerve in rabbits supported by morphologic and electrophysiologic data was used to evaluate the effects of ACTH4-10 on nerve fiber regeneration. Treated animals showed a statistically significant higher regeneration rate than did control rabbits. Fiber density and mean diameters of myelinated nerve fibers were measured in semithin nerve sections at 1 and 3 cm distal from the crushed point at three different time points. Nerve fiber density results were higher in ACTH4-10- than in vehicletreated rabbits. This difference showed an unequivocal trend and attained a statistically significant level in the sections 3 cm distal from the crush. ACTH4-10 seemed therefore to have a beneficial effect on nerve fiber regeneration.

Original languageEnglish
Pages (from-to)454-460
Number of pages7
JournalExperimental Neurology
Volume99
Issue number2
DOIs
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neurology

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