TY - JOUR
T1 - Effect of acute administration of l-acetyl carnitine on cerebral blood flow in patients with chronic cerebral infarct
AU - Postiglione, Alfredo
AU - Soricelli, Andrea
AU - Cicerano, Umberto
AU - Mansi, Luigi
AU - De Chiara, Simona
AU - Gallotta, Giovanni
AU - Schettini, Gennaro
AU - Salvatore, Marco
PY - 1991
Y1 - 1991
N2 - The effect of l-acetyl carnitine (l-AC) on cerebral blood flow (CBF) was evaluated in 20 patients with chronic cerebrovascular disease, who suffered an ischaemic stroke at least 6 months before the study. All patients performed a CT scan and were investigated with xenon-133 by brain dedicated single photon emission computed tomography (SPECT, Tomomatic 32, Medimatic Inc., Copenhagen). A single high dose (1.5 g) of l-acetyl carnitine was intravenously administered to 10 patients, while sodium acetate as placebo was injected to 10 other subjects. Cerebral blood flow (ml/min × 100 g) was evaluated before and 45 min after the injection. No changes were observed after placebo injection (43 ± 12 ml/min × 100 g versus 43 ± 10 ml/min × 100 g). CBF increased (from 42 ± 9 ml/min × 100 g to 46 ± 9, P
AB - The effect of l-acetyl carnitine (l-AC) on cerebral blood flow (CBF) was evaluated in 20 patients with chronic cerebrovascular disease, who suffered an ischaemic stroke at least 6 months before the study. All patients performed a CT scan and were investigated with xenon-133 by brain dedicated single photon emission computed tomography (SPECT, Tomomatic 32, Medimatic Inc., Copenhagen). A single high dose (1.5 g) of l-acetyl carnitine was intravenously administered to 10 patients, while sodium acetate as placebo was injected to 10 other subjects. Cerebral blood flow (ml/min × 100 g) was evaluated before and 45 min after the injection. No changes were observed after placebo injection (43 ± 12 ml/min × 100 g versus 43 ± 10 ml/min × 100 g). CBF increased (from 42 ± 9 ml/min × 100 g to 46 ± 9, P
KW - brain imaging
KW - cerebral blood flow
KW - cerebrovascular disease
KW - neuropharmacology
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U2 - 10.1016/S1043-6618(05)80083-0
DO - 10.1016/S1043-6618(05)80083-0
M3 - Article
C2 - 2068049
AN - SCOPUS:0025767765
VL - 23
SP - 241
EP - 246
JO - Pharmacological Research
JF - Pharmacological Research
SN - 1043-6618
IS - 3
ER -