Effect of acute administration of l-acetyl carnitine on cerebral blood flow in patients with chronic cerebral infarct

Alfredo Postiglione, Andrea Soricelli, Umberto Cicerano, Luigi Mansi, Simona De Chiara, Giovanni Gallotta, Gennaro Schettini, Marco Salvatore

Research output: Contribution to journalArticle

Abstract

The effect of l-acetyl carnitine (l-AC) on cerebral blood flow (CBF) was evaluated in 20 patients with chronic cerebrovascular disease, who suffered an ischaemic stroke at least 6 months before the study. All patients performed a CT scan and were investigated with xenon-133 by brain dedicated single photon emission computed tomography (SPECT, Tomomatic 32, Medimatic Inc., Copenhagen). A single high dose (1.5 g) of l-acetyl carnitine was intravenously administered to 10 patients, while sodium acetate as placebo was injected to 10 other subjects. Cerebral blood flow (ml/min × 100 g) was evaluated before and 45 min after the injection. No changes were observed after placebo injection (43 ± 12 ml/min × 100 g versus 43 ± 10 ml/min × 100 g). CBF increased (from 42 ± 9 ml/min × 100 g to 46 ± 9, P

Original languageEnglish
Pages (from-to)241-246
Number of pages6
JournalPharmacological Research
Volume23
Issue number3
DOIs
Publication statusPublished - 1991

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Keywords

  • brain imaging
  • cerebral blood flow
  • cerebrovascular disease
  • neuropharmacology

ASJC Scopus subject areas

  • Pharmacology

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