Effect of acute administration of l-acetyl carnitine on cerebral blood flow in patients with chronic cerebral infarct

Alfredo Postiglione; Andrea Soricelli; Umberto Cicerano; Luigi Mansi; Simona De Chiara; Giovanni Gallotta; Gennaro Schettini; Marco Salvatore

doi:10.1016/S1043-6618(05)80083-0

Effect of acute administration of l-acetyl carnitine on cerebral blood flow in patients with chronic cerebral infarct

Alfredo Postiglione, Andrea Soricelli, Umberto Cicerano, Luigi Mansi, Simona De Chiara, Giovanni Gallotta, Gennaro Schettini, Marco Salvatore

IRCCS SDN

Research output: Contribution to journal › Article › peer-review

Abstract

The effect of l-acetyl carnitine (l-AC) on cerebral blood flow (CBF) was evaluated in 20 patients with chronic cerebrovascular disease, who suffered an ischaemic stroke at least 6 months before the study. All patients performed a CT scan and were investigated with xenon-133 by brain dedicated single photon emission computed tomography (SPECT, Tomomatic 32, Medimatic Inc., Copenhagen). A single high dose (1.5 g) of l-acetyl carnitine was intravenously administered to 10 patients, while sodium acetate as placebo was injected to 10 other subjects. Cerebral blood flow (ml/min × 100 g) was evaluated before and 45 min after the injection. No changes were observed after placebo injection (43 ± 12 ml/min × 100 g versus 43 ± 10 ml/min × 100 g). CBF increased (from 42 ± 9 ml/min × 100 g to 46 ± 9, P

Original language	English
Pages (from-to)	241-246
Number of pages	6
Journal	Pharmacological Research
Volume	23
Issue number	3
DOIs	https://doi.org/10.1016/S1043-6618(05)80083-0
Publication status	Published - 1991

Keywords

brain imaging
cerebral blood flow
cerebrovascular disease
neuropharmacology

ASJC Scopus subject areas

Pharmacology

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Effect of acute administration of l-acetyl carnitine on cerebral blood flow in patients with chronic cerebral infarct. / Postiglione, Alfredo; Soricelli, Andrea; Cicerano, Umberto; Mansi, Luigi; De Chiara, Simona; Gallotta, Giovanni; Schettini, Gennaro; Salvatore, Marco.

In: Pharmacological Research, Vol. 23, No. 3, 1991, p. 241-246.

Research output: Contribution to journal › Article › peer-review

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