Effect of acute exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on humoral antibody production in mice

A. Vecchi, A. Mantovani, M. Sironi, W. Luini, M. Cairo, S. Garattini

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of single dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, 1.2, 6 or 30 μg/kg i.p.) on primary humoral antibody production was studied in young adult C57 BL/6J mice. TCDD profoundly suppressed the primary response to thymus-dependent (sheep erythrocytes) and independent (type III pneumococcal polysaccharide) antigens. The inhibitory effect of TCDD was still detectable 42 days after treatment. In contrast, under these experimental conditions, in vitro lymphoproliferative responses to Concanavalin A (Con A) and bacterial lypopolysaccharides and the ability to mediate graft versus host reaction were not significantly affected per unit number of lymphoid cells.

Original languageEnglish
Pages (from-to)337-342
Number of pages6
JournalChemico-Biological Interactions
Volume30
Issue number3
DOIs
Publication statusPublished - 1980

ASJC Scopus subject areas

  • Toxicology

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