Effect of age and sex on efficacy and tolerability of β blockers in patients with heart failure with reduced ejection fraction: Individual patient data meta-analysis

Dipak Kotecha, Luis Manzano, Henry Krum, Giuseppe Rosano, Jane Holmes, Douglas G. Altman, Peter D. Collins, Milton Packer, John Wikstrand, Andrew J S Coats, John G F Cleland, Paulus Kirchhof, Thomas G. Von Lueder, Alan S. Rigby, Bert Andersson, Gregory Y H Lip, Dirk J. Van Veldhuisen, Marcelo C. Shibata, Hans Wedel, Michael BöhmMarcus D. Flather

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVES: To determine the efficacy and tolerability of β blockers in a broad age range of women and men with heart failure with reduced ejection fraction (HFrEF) by pooling individual patient data from placebo controlled randomised trials. DESIGN: Prospectively designed meta-analysis of individual patient data from patients aged 40-85 in sinus rhythm at baseline, with left ventricular ejection fraction

Original languageEnglish
Article numberi1855
JournalBritish Medical Journal
Volume353
DOIs
Publication statusPublished - Apr 20 2016

ASJC Scopus subject areas

  • Medicine(all)

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