Effect of age on β-adrenergic receptors on cerebral microvessels

Hideyuki Kobayashi, Tiziana Maoret, Pier Franco Spano, Marco Trabucchi

Research output: Contribution to journalArticlepeer-review

Abstract

The responsiveness of β-adrenergic receptors in cerebral microvessels was studied in aged rats by measuring cAMP formation induced by norepinephrine and [125I]iodohydroxybenzylpindolol binding. The density of β-receptor sites is reduced by aging in the rat cerebral microvessels. These results suggest that the changes in brain circulation during aging may be at least partially due to a reduction of the β-adrenergic control of cerebral microvessels.

Original languageEnglish
Pages (from-to)374-377
Number of pages4
JournalBrain Research
Volume244
Issue number2
DOIs
Publication statusPublished - Jul 29 1982

Keywords

  • aging
  • cerebral microvessel
  • β-adrenergic receptor

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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