Effect of aging on myocardial perfusion reserve

N. G. Uren, P. G. Camici, J. A. Melin, A. Bol, B. De Bruyne, J. Radvan, I. Olivotto, S. D. Rosen, M. Impallomeni, W. Wijns

Research output: Contribution to journalArticlepeer-review


Myocardial perfusion reserve (hyperemic/basal myocardial blood flow) describes vasodilator responsiveness of coronary-resistive vessels. The effect of aging and gender on myocardial perfusion reserve remains controversial. Methods: We studied 56 normal volunteers (21 women, 35 men; aged 50 ± 20 yr, range 21-86 yr) with 15O-water PET to measure myocardial blood flow during basal and hyperemic states with intravenous dipyridamole (0.56 mg/kg, n = 46) or adenosine (140 μg/kg/min, n = 10). For comparative analysis, patients were grouped according to age:

Original languageEnglish
Pages (from-to)2032-2036
Number of pages5
JournalJournal of Nuclear Medicine
Issue number11
Publication statusPublished - 1995


  • dipyridamole
  • myocardial perfusion reserve
  • oxygen-15-water
  • positron emission tomography

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology


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