Effect of aliskiren in patients with heart failure according to background dose of ACE inhibitor: A retrospective analysis of the aliskiren observation of heart failure treatment (ALOFT) trial

Novalia P. Sidik, Scott D. Solomon, Roberto Latini, Aldo P. Maggioni, Melanie Wright, Claudio R. Gimpelewicz, Bertram Pitt, John J V McMurray

Research output: Contribution to journalArticle


Aims: To compare the effect of the direct renin inhibitor aliskiren on neurohumoral activity in heart failure patients treated with low-dose and high-dose ACE inhibitor. Methods: A retrospective analysis of the ALOFT trial. Comparison of the effects of 6 months treatment with aliskiren (versus placebo) in patients receiving

Original languageEnglish
Pages (from-to)315-321
Number of pages7
JournalCardiovascular Drugs and Therapy
Issue number4
Publication statusPublished - Aug 2011



  • Angiotensin
  • Heart failure
  • Natriuretic peptides
  • Renin

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Cardiology and Cardiovascular Medicine
  • Pharmacology

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