Effect of amantadine on drug induced parkinsonism: Relationship between plasma levels and effect

G. M. Pacifici, M. Nardini, P. Ferrari, R. Latini, C. Fieschi, P. L. Morselli

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Amantadine, administered at a dose of 200 mg/day, antagonized the extrapyramidal symptomatology induced by neuroleptic drugs in 15 psychiatric patients. Steady state levels were reached within 4-7 days of treatment. Individual plasma levels ranged from 200-900 ng/ml. Apparent plasma half lives varied from 10-28.5 hr with an apparent V(D) of 200-400 litres. A significant relationship was found between the plasma levels of amantadine and the effects on the extrapyramidal symptomatology. The data suggest a direct effect of amantadine on dopaminergic receptors.

Original languageEnglish
Pages (from-to)883-889
Number of pages7
JournalBritish Journal of Clinical Pharmacology
Volume3
Issue number5
Publication statusPublished - 1976

Fingerprint

Amantadine
Parkinsonian Disorders
Pharmaceutical Preparations
Antipsychotic Agents
Psychiatry
Therapeutics

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Pacifici, G. M., Nardini, M., Ferrari, P., Latini, R., Fieschi, C., & Morselli, P. L. (1976). Effect of amantadine on drug induced parkinsonism: Relationship between plasma levels and effect. British Journal of Clinical Pharmacology, 3(5), 883-889.

Effect of amantadine on drug induced parkinsonism : Relationship between plasma levels and effect. / Pacifici, G. M.; Nardini, M.; Ferrari, P.; Latini, R.; Fieschi, C.; Morselli, P. L.

In: British Journal of Clinical Pharmacology, Vol. 3, No. 5, 1976, p. 883-889.

Research output: Contribution to journalArticle

Pacifici, GM, Nardini, M, Ferrari, P, Latini, R, Fieschi, C & Morselli, PL 1976, 'Effect of amantadine on drug induced parkinsonism: Relationship between plasma levels and effect', British Journal of Clinical Pharmacology, vol. 3, no. 5, pp. 883-889.
Pacifici, G. M. ; Nardini, M. ; Ferrari, P. ; Latini, R. ; Fieschi, C. ; Morselli, P. L. / Effect of amantadine on drug induced parkinsonism : Relationship between plasma levels and effect. In: British Journal of Clinical Pharmacology. 1976 ; Vol. 3, No. 5. pp. 883-889.
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