Effect of amantadine on drug induced parkinsonism: Relationship between plasma levels and effect

G. M. Pacifici, M. Nardini, P. Ferrari, R. Latini, C. Fieschi, P. L. Morselli

Research output: Contribution to journalArticlepeer-review

Abstract

Amantadine, administered at a dose of 200 mg/day, antagonized the extrapyramidal symptomatology induced by neuroleptic drugs in 15 psychiatric patients. Steady state levels were reached within 4-7 days of treatment. Individual plasma levels ranged from 200-900 ng/ml. Apparent plasma half lives varied from 10-28.5 hr with an apparent V(D) of 200-400 litres. A significant relationship was found between the plasma levels of amantadine and the effects on the extrapyramidal symptomatology. The data suggest a direct effect of amantadine on dopaminergic receptors.

Original languageEnglish
Pages (from-to)883-889
Number of pages7
JournalBritish Journal of Clinical Pharmacology
Volume3
Issue number5
Publication statusPublished - 1976

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Fingerprint Dive into the research topics of 'Effect of amantadine on drug induced parkinsonism: Relationship between plasma levels and effect'. Together they form a unique fingerprint.

Cite this