Amantadine, administered at a dose of 200 mg/day, antagonized the extrapyramidal symptomatology induced by neuroleptic drugs in 15 psychiatric patients. Steady state levels were reached within 4-7 days of treatment. Individual plasma levels ranged from 200-900 ng/ml. Apparent plasma half lives varied from 10-28.5 hr with an apparent V(D) of 200-400 litres. A significant relationship was found between the plasma levels of amantadine and the effects on the extrapyramidal symptomatology. The data suggest a direct effect of amantadine on dopaminergic receptors.
|Number of pages||7|
|Journal||British Journal of Clinical Pharmacology|
|Publication status||Published - 1976|
ASJC Scopus subject areas
- Pharmacology (medical)
- Pharmacology, Toxicology and Pharmaceutics(all)