Effect of amphetamine and fenfluramine on brain noradrenaline and MOPEG-SO4

Gabriella Calderini, Paolo Lucio Morselli, Silvio Garattini

Research output: Contribution to journalArticlepeer-review

Abstract

I.p. administration of d-amphetamine sulphate and fenfluramine · HCl at various doses induced significant modifications of brain noradrenaline (NA) and MOPEG-SO4 (3-methoxy-4-hydrorxyphenylethyleneglycol) in the rat. Both drugs induced a decrease in brain noradrenaline but the two compounds seem to interact with the central noradrenergic system through a different mechanism. The decreased levels of noradrenaline after 1-fenfluramine administration were paralleled by increased MOPEG-SO4 levels. The d-isomer of fenfluramine was less active than the l-isomer. Amphetamine was considerably more effective than 1-fenfluramine in reducing NA concentration. However, in spite of the long lasting effect on noradrenaline levels the i.p. administration of amphetamine did not lead to an increased MOPEG-SO4 concentrations suggesting a more complex interaction with the noradrenergic system.

Original languageEnglish
Pages (from-to)345-350
Number of pages6
JournalEuropean Journal of Pharmacology
Volume34
Issue number2
DOIs
Publication statusPublished - 1975

Keywords

  • 1-Fenfluramine
  • Brain MOPEG-SO
  • Brain noradrenaline
  • d-Amphetamine
  • d-Fenfluramine
  • Noradrenergic central mechanism

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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