Abstract
I.p. administration of d-amphetamine sulphate and fenfluramine · HCl at various doses induced significant modifications of brain noradrenaline (NA) and MOPEG-SO4 (3-methoxy-4-hydrorxyphenylethyleneglycol) in the rat. Both drugs induced a decrease in brain noradrenaline but the two compounds seem to interact with the central noradrenergic system through a different mechanism. The decreased levels of noradrenaline after 1-fenfluramine administration were paralleled by increased MOPEG-SO4 levels. The d-isomer of fenfluramine was less active than the l-isomer. Amphetamine was considerably more effective than 1-fenfluramine in reducing NA concentration. However, in spite of the long lasting effect on noradrenaline levels the i.p. administration of amphetamine did not lead to an increased MOPEG-SO4 concentrations suggesting a more complex interaction with the noradrenergic system.
| Original language | English |
|---|---|
| Pages (from-to) | 345-350 |
| Number of pages | 6 |
| Journal | European Journal of Pharmacology |
| Volume | 34 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1975 |
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Keywords
- 1-Fenfluramine
- Brain MOPEG-SO
- Brain noradrenaline
- d-Amphetamine
- d-Fenfluramine
- Noradrenergic central mechanism
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Pharmacology
Cite this
Effect of amphetamine and fenfluramine on brain noradrenaline and MOPEG-SO4 . / Calderini, Gabriella; Morselli, Paolo Lucio; Garattini, Silvio.
In: European Journal of Pharmacology, Vol. 34, No. 2, 1975, p. 345-350.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of amphetamine and fenfluramine on brain noradrenaline and MOPEG-SO4
AU - Calderini, Gabriella
AU - Morselli, Paolo Lucio
AU - Garattini, Silvio
PY - 1975
Y1 - 1975
N2 - I.p. administration of d-amphetamine sulphate and fenfluramine · HCl at various doses induced significant modifications of brain noradrenaline (NA) and MOPEG-SO4 (3-methoxy-4-hydrorxyphenylethyleneglycol) in the rat. Both drugs induced a decrease in brain noradrenaline but the two compounds seem to interact with the central noradrenergic system through a different mechanism. The decreased levels of noradrenaline after 1-fenfluramine administration were paralleled by increased MOPEG-SO4 levels. The d-isomer of fenfluramine was less active than the l-isomer. Amphetamine was considerably more effective than 1-fenfluramine in reducing NA concentration. However, in spite of the long lasting effect on noradrenaline levels the i.p. administration of amphetamine did not lead to an increased MOPEG-SO4 concentrations suggesting a more complex interaction with the noradrenergic system.
AB - I.p. administration of d-amphetamine sulphate and fenfluramine · HCl at various doses induced significant modifications of brain noradrenaline (NA) and MOPEG-SO4 (3-methoxy-4-hydrorxyphenylethyleneglycol) in the rat. Both drugs induced a decrease in brain noradrenaline but the two compounds seem to interact with the central noradrenergic system through a different mechanism. The decreased levels of noradrenaline after 1-fenfluramine administration were paralleled by increased MOPEG-SO4 levels. The d-isomer of fenfluramine was less active than the l-isomer. Amphetamine was considerably more effective than 1-fenfluramine in reducing NA concentration. However, in spite of the long lasting effect on noradrenaline levels the i.p. administration of amphetamine did not lead to an increased MOPEG-SO4 concentrations suggesting a more complex interaction with the noradrenergic system.
KW - 1-Fenfluramine
KW - Brain MOPEG-SO
KW - Brain noradrenaline
KW - d-Amphetamine
KW - d-Fenfluramine
KW - Noradrenergic central mechanism
UR - http://www.scopus.com/inward/record.url?scp=0016596710&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0016596710&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(75)90261-7
DO - 10.1016/0014-2999(75)90261-7
M3 - Article
VL - 34
SP - 345
EP - 350
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 2
ER -