Effect of an antiserotoninergic drug, metergoline, on the ACTH and cortisol response to insulin hypoglycemia and lysine vasopressin in man

F. Cavagnini, U. Raggi, P. Micossi, A. Di Landro, C. Invitti

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of metergoline, a specific antiserotoninergic drug, on ACTH secretion was investigated in 29 normal volunteers and in 4 patients with increased ACTH production (3 with Addison's disease, 1 with Cushing's disease). In 15 normal subjects, a 4 day treatment with 10 mg daily of metergoline significantly blunted the ACTH response to insulin hypoglycemia. Mean peak ACTH values before and after treatment were, respectively, 333 ± 39.2 (SE) and 235 ± 38.8 pg/ml (P

Original languageEnglish
Pages (from-to)306-312
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Volume43
Issue number2
Publication statusPublished - 1976

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

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