Effect of antibiotic-loaded chitosan nanodroplets on Enterococci isolated from chronic ulcers of the lower limbs

Daniela Mazzaccaro, Rosalia Ticozzi, Sarah D'Alessandro, Serena Delbue, Giovanni Nano, Elena Costa, Monica Argenziano, Roberta Cavalli, Mauro Prato, Nicoletta Basilico

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: To investigate the effect of a new platform of nanocarriers, called nanodroplets (NDs), to enhance the in vitro activity of vancomycin (Vm), against bacterial colonies isolated from chronic ulcers of the lower limbs. Materials & methods: Oxygen-loaded nanodroplets (OLNDs) or oxygen-free nanodroplets (OFNDs) were loaded with Vm (Vm-OLNDs and Vm-OFNDs). MIC and minimal bactericidal concentrations were evaluated for Vm, OLNDs and OFNDs loaded with Vm, OLNDs and OFNDs. Results & conclusion: Nanodroplets, either with or without oxygen, appeared as a suitable platform of antibiotic nanocarriers to enhance the antibacterial effects of Vm against Enterococci, with a decrease in both MIC and minimal bactericidal concentration against Vm-resistant Enterococci strains.

Original languageEnglish
Pages (from-to)1227-1236
Number of pages10
JournalFuture Microbiology
Volume15
Issue number13
DOIs
Publication statusPublished - Sep 2020

Keywords

  • chitosan
  • chronic ulcers
  • Enterococcus
  • nanodroplets

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

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