EFFETTI DEL TRATTAMENTO ANTIPERTENSIVO SULLE ALTERAZIONI VASCOLARI DEL DISTRETTO CAROTIDEO

Translated title of the contribution: Effect of antihypertensive treatment on carotid vascular abnormalities

F. Pompeo, N. De Luca, R. Marchegiano, P. Gisonni, G. Iovino, F. D'Auria, L. Del Mastro, P. Simonelli, B. Trimarco

Research output: Contribution to journalArticlepeer-review

Abstract

The carotid artery is one of the most important sites in the progression of atherosclerotic lesions. Atherosclerosis is known to be determined by a variety of factors, among which arterial hypertension is one of the most important. Blood pressure control by antihypertensive treatment is thus of great benefit in management of atherosclerosis, particulary in view of the direct action of some classes of antihypertensive agents on atheromatous lesions. Today, modern diagnostic technique allow a non-invasive examination of the artery wall (B-mode ultrasound and pulsed-Doppler), so that early detection of structural and functional alterations is possible. In order to evaluate the efficacy of the long term blood pressnre reduction in the progression and/or in the regression of cardiovascular structural abnormalities, we studied intima-media thickness and arterial compliance during one-year antihypertensive treatment with a new calcium-antagonist, lacidipine, or a diuretic hydrochlorothiazide. In both groups we observed a comparable blood pressure reduction (lacidipine: from 166 ± 5/100 ± 1 to 142 ± 4/88 ± 2 mmHg; hydrochlorothiazide: from 154 ± 5/102 ± 2 to 140 ± 4/88 ± mmHg; both p <0.01). On the contrary, only in patients treated with lacidipine did we obtain a significant improvement in carotid blood flow (383 ± 16 vs 411 ± 16 ml/min p

Translated title of the contributionEffect of antihypertensive treatment on carotid vascular abnormalities
Original languageItalian
Pages (from-to)511-515
Number of pages5
JournalMinerva Cardioangiologica
Volume42
Issue number11
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Effect of antihypertensive treatment on carotid vascular abnormalities'. Together they form a unique fingerprint.

Cite this