Effect of antipsychotic drugs on brain-derived neurotrophic factor expression under reduced N-methyl-D-aspartate receptor activity

Fabio Fumagalli, Raffaella Molteni, Mila Roceri, Francesco Bedogni, Raffaella Santero, Claudia Fossati, Massimo Gennarelli, Giorgio Racagni, Marco Andrea Riva

Research output: Contribution to journalArticle

Abstract

Brain-derived neurotrophic factor (BDNF) promotes a variety of neuromodulatory processes during development as well as in adulthood. This neurotrophin has been associated with synaptic plasticity, suggesting that its regulation may represent one of the mechanisms through which psychotropic drugs alter brain function. Because reduced glutamatergic function represents a major feature of schizophrenia, we investigated the effects of the concomitant administration of haloperidol or olanzapine with the N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 on BDNF expression. MK-801 reduces the hippocampal expression of the neurotrophin; this effect was exacerbated by haloperidol, but it was normalized by olanzapine. Our data reveal a fine tuning of BDNF biosynthesis and a differential modulation by antipsychotic drugs when NMDA-mediated transmission is reduced, suggesting that haloperidol and olanzapine can produce different effects on brain plasticity through the modulation of BDNF expression.

Original languageEnglish
Pages (from-to)622-628
Number of pages7
JournalJournal of Neuroscience Research
Volume72
Issue number5
DOIs
Publication statusPublished - Jun 1 2003

Keywords

  • Haloperidol
  • Neurotrophic factors
  • NMDA receptors
  • Olanzapine
  • Schizophrenia

ASJC Scopus subject areas

  • Neuroscience(all)

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