Influenza di terapie antiretrovirali sullo spessore medio-intimale carotideo in pazienti HIV-positivi

Translated title of the contribution: Effect of antiretroviral therapy on carotid intima-media thickness in HIV-infected patients

Sergio Ferraro, Stefania Paolillo, Miriam Gargiulo, Pierluigi Costanzo, Paolo Maggi, Antonio Chirianni, Massimo Chiariello, Pasquale Perrone Filardi

Research output: Contribution to journalArticlepeer-review

Abstract

Background. The introduction of highly active antiretroviral therapy reduced HIV-associated morbidity and mortality, at the cost of adverse metabolic effects that increase cardiovascular risk. The aim of this study was to evaluate the impact of exposure to protease inhibitors (PI) compared with exposure to non-nucleoside reverse transcriptase inhibitors (NNRTI) on carotid intima-media thickness (IMT) and blood flow velocity and to measure vascular involvement over a 2-year follow-up in HIV-infected patients treated with PI. Methods. Thirty-five HIV-infected patients treated with PI (group I) and 15 patients treated with NNRTI (group II) underwent epiaortic vessel ultrasonography. The same evaluation was obtained in a group of 20 healthy subjects. After 20 ± 2 months, 22 patients of group I were re-evaluated and the follow-up data were compared with those obtained at baseline. Results. The ANOVA test showed a significant difference among the three groups for IMT and flow velocities. Bonferroni analyses showed significant differences in IMT and flow velocities in group I vs group II vs controls: IMT of the right common carotid artery was 0.742 ± 0.135 mm in group I vs 0.642 ± 0.131 mm in group II (p

Translated title of the contributionEffect of antiretroviral therapy on carotid intima-media thickness in HIV-infected patients
Original languageItalian
Pages (from-to)596-601
Number of pages6
JournalGiornale Italiano di Cardiologia
Volume10
Issue number9
Publication statusPublished - 2009

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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